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    C47E12.3 alpha-1,2-Mannosidase [ Caenorhabditis elegans ]

    Gene ID: 177857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C47E12.3
    Official Full Name
    alpha-1,2-Mannosidase
    Primary source
    WormBase:WBGene00008148
    Locus tag
    CELE_C47E12.3
    See related
    AllianceGenome:WB:WBGene00008148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in head neurons and intestine. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C47E12.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (9999160..10001848, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene E1 ubiquitin-activating enzyme Neighboring gene Inorganic pyrophosphatase 1 Neighboring gene ADP/ATP translocase Neighboring gene putative serine--tRNA ligase, cytoplasmic Neighboring gene DUF1874 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum mannose trimming IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-Mannosidase
    NP_001293897.1
    • Partially confirmed by transcript evidence
    NP_501802.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9999160..10001848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306968.3 → NP_001293897.1  alpha-1,2-Mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACH9
      Conserved Domains (1) summary
      pfam01532
      Location:54 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    2. NM_069401.6 → NP_501802.2  alpha-1,2-Mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501802.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18679
      Conserved Domains (1) summary
      pfam01532
      Location:54 → 504
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein
    Heading Accession and Version

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