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    erfa-3 Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    erfa-3
    Official Full Name
    Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00010405
    Locus tag
    CELE_H19N07.1
    See related
    AllianceGenome:WB:WBGene00010405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in translation. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in several structures, including anal depressor muscle; excretory cell; nervous system; rectal epithelium; and reproductive system. Orthologous to human GSPT1 (G1 to S phase transition 1) and GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See erfa-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (11110100..11113091, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein Neighboring gene LYR motif-containing protein 5 Neighboring gene pseudo Neighboring gene Ubiquitin carboxyl-terminal hydrolase 7 Neighboring gene MRG domain-containing protein Neighboring gene O-acyltransferase;diacylglycerol O-acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Auxin-independent depletion of degron-tagged proteins by TIR1. Schiksnis E, et al. MicroPubl Biol, 2020 Jan 28. PMID 32550513, Free PMC Article
    2. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
    4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein
    NP_001256292.1
    • Confirmed by transcript evidence
    NP_001367276.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11110100..11113091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269363.4 → NP_001256292.1  Eukaryotic peptide chain release factor GTP-binding subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45622
      Conserved Domains (2) summary
      COG5256
      Location:105 → 532
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam06121
      Location:24 → 94
      DUF959; Domain of Unknown Function (DUF959)

    2. NM_001380755.1 → NP_001367276.1  GTP-eEF1A C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P8A2
      Conserved Domains (1) summary
      cl02786
      Location:1 → 40
      Translation_factor_III; Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
    Nucleotide Protein
    Heading Accession and Version

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