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    • Showing Current items.

    lin-13 Zinc finger protein lin-13 [ Caenorhabditis elegans ]

    Gene ID: 176083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-13
    Official Full Name
    Zinc finger protein lin-13
    Primary source
    WormBase:WBGene00003002
    Locus tag
    CELE_C03B8.4
    See related
    AllianceGenome:WB:WBGene00003002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of vulval development. Located in nucleus. Is expressed in several structures, including epithelial cell; excretory cell; intestine; nervous system; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-13 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    22
    Sequence:
    Chromosome: III; NC_003281.10 (7700338..7709491, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene BRCT domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development. Coustham V, et al. Dev Biol, 2006 Sep 15. PMID 16890929
    2. Perinuclear distribution of heterochromatin in developing C. elegans embryos. Grant J, et al. Chromosome Res, 2010 Dec. PMID 21116703
    3. A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. McMurchy AN, et al. Elife, 2017 Mar 15. PMID 28294943, Free PMC Article
    4. The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis. Kozlowski L, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24715729, Free PMC Article
    5. Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Katz WS, et al. Cell, 1995 Jul 28. PMID 7628018

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the LIN-13/HPL-2 complex may physically link a subset of the Rb related synMuv proteins to chromatin
      Title: The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein lin-13
    NP_498678.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7700338..7709491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066277.6 → NP_498678.3  Zinc finger protein lin-13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498678.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11107, Q9NBV2
      Conserved Domains (1) summary
      sd00017
      Location:961 → 982
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11107.2

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