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    arx-4 putative actin-related protein 2/3 complex subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 175247, updated on 9-Dec-2024

    Summary

    Official Symbol
    arx-4
    Official Full Name
    putative actin-related protein 2/3 complex subunit 2
    Primary source
    WormBase:WBGene00021170
    Locus tag
    CELE_Y6D11A.2
    See related
    AllianceGenome:WB:WBGene00021170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Is expressed in head; intestine; pharynx; and tail. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See arx-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (862306..865398)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative ATP-dependent DNA helicase Q1 Neighboring gene Exoribonuclease phosphorolytic domain-containing protein Neighboring gene ZSWIM3 N-terminal domain-containing protein Neighboring gene Protein DPCD

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative actin-related protein 2/3 complex subunit 2
    NP_001370783.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      862306..865398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384017.1NP_001370783.1  putative actin-related protein 2/3 complex subunit 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WTM6
      Conserved Domains (1) summary
      pfam04045
      Location:57286
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc