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    eif-3.F Eukaryotic translation initiation factor 3 subunit F [ Caenorhabditis elegans ]

    Gene ID: 174478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif-3.F
    Official Full Name
    Eukaryotic translation initiation factor 3 subunit F
    Primary source
    WormBase:WBGene00001229
    Locus tag
    CELE_D2013.7
    See related
    AllianceGenome:WB:WBGene00001229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Involved in translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eif-3.F in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9331643..9333970)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Dynamin-like GTPase OPA1, mitochondrial Neighboring gene GRAM domain-containing protein Neighboring gene ncRNA Neighboring gene Sterol regulatory element-binding protein cleavage-activating protein;WD_REPEATS_REGION domain-containing protein Neighboring gene Tubulin--tyrosine ligase-like protein 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Lee EC, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23076791, Free PMC Article
    2. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article
    3. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
    4. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
    5. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 3 subunit F
    NP_495988.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9331643..9333970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063587.7 → NP_495988.1  Eukaryotic translation initiation factor 3 subunit F [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495988.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18967
      Conserved Domains (1) summary
      cd08064
      Location:7 → 291
      MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18967.1

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