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    glna-2 Putative glutaminase 2;glutaminase [ Caenorhabditis elegans ]

    Gene ID: 174282, updated on 9-Dec-2024

    Summary

    Official Symbol
    glna-2
    Official Full Name
    Putative glutaminase 2;glutaminase
    Primary source
    WormBase:WBGene00008435
    Locus tag
    CELE_DH11.1
    See related
    AllianceGenome:WB:WBGene00008435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to be located in mitochondrion. Is expressed in several structures, including body wall musculature; head neurons; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to several human genes including GLS (glutaminase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See glna-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (8008634..8011633)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Early embryogenesis protein zyg-11

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Putative glutaminase 2;glutaminase
    NP_001305214.1
    • Confirmed by transcript evidence
    NP_001380189.1
    • Confirmed by transcript evidence
    NP_495675.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8008634..8011633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393130.1NP_001380189.1  glutaminase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XRH7
      Conserved Domains (3) summary
      sd00045
      Location:254286
      ANK; ANK repeat [structural motif]
      pfam04960
      Location:1197
      Glutaminase
      pfam12796
      Location:227308
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_063274.4NP_495675.1  Putative glutaminase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19013
      Conserved Domains (4) summary
      cd00204
      Location:486567
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:171458
      Glutaminase; Glutaminase
      pfam13637
      Location:484534
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:513545
      ANK; ANK repeat [structural motif]
    3. NM_001318285.3NP_001305214.1  glutaminase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XRA9
      Conserved Domains (3) summary
      sd00045
      Location:98130
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:71152
      Ank_2; Ankyrin repeats (3 copies)
      cl00907
      Location:143
      Glutaminase