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    cal-8 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cal-8
    Official Full Name
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00017394
    Locus tag
    CELE_F12A10.5
    See related
    AllianceGenome:WB:WBGene00017394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cal-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (5480484..5482041, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Receptor-type tyrosine-protein phosphatase;protein-tyrosine-phosphatase Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein bS16m Neighboring gene Interleukin cytokine receptor-related protein 2 Neighboring gene Putative zinc finger protein F56D1.1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of the multiple calmodulin-like cal genes in C. elegans and in nematodes. Karabinos A. Dev Genes Evol, 2016 Sep. PMID 27558386
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein
    NP_495043.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5480484..5482041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062642.4 → NP_495043.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09980
      Conserved Domains (2) summary
      PTZ00184
      Location:7 → 142
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:81 → 143
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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