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    him-17 High Incidence of Males (increased X chromosome loss) [ Caenorhabditis elegans ]

    Gene ID: 179800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    him-17
    Official Full Name
    High Incidence of Males (increased X chromosome loss)
    Primary source
    WormBase:WBGene00001874
    Locus tag
    CELE_T09E8.2
    See related
    AllianceGenome:WB:WBGene00001874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in germline cell cycle switching, mitotic to meiotic cell cycle and resolution of meiotic recombination intermediates. Located in chromatin. Is expressed in several structures, including anal depressor muscle; excretory cell; germ line; intestine; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See him-17 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (13176711..13180185)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Non-centrosomal microtubule array protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein cornichon homolog 1 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widespread transposon co-option in the Caenorhabditis germline regulatory network. Carelli FN, et al. Sci Adv, 2022 Dec 16. PMID 36525485, Free PMC Article
    2. Modifying histones and initiating meiotic recombination; new answers to an old question. Maleki S, et al. Cell, 2004 Aug 20. PMID 15315752
    3. A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision. Bessler JB, et al. Genetics, 2007 Apr. PMID 17237503, Free PMC Article
    4. HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis. Nadarajan S, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33883277, Free PMC Article
    5. C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination. Reddy KC, et al. Cell, 2004 Aug 20. PMID 15315757

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis.
      Title: HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis.
    2. cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature
      Title: A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision.
    3. HIM-17 has a role in chromatin modification for initiation of meiotic recombination
      Title: C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in germline cell cycle switching, mitotic to meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germline cell cycle switching, mitotic to meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    High Incidence of Males (increased X chromosome loss)
    NP_506277.1
    • Product from WormBase gene class him;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13176711..13180185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073876.5 → NP_506277.1  High Incidence of Males (increased X chromosome loss) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22360
    Nucleotide Protein
    Heading Accession and Version

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