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    nrde-4 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrde-4
    Official Full Name
    ANK_REP_REGION domain-containing protein
    Primary source
    WormBase:WBGene00001584
    Locus tag
    CELE_F45E4.10
    See related
    AllianceGenome:WB:WBGene00001584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nrde-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (7646320..7654262, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene HMG box-containing protein 5 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans. Jiao AL, et al. PLoS One, 2018. PMID 29324872, Free PMC Article
    2. Small RNAs, RNAi and the inheritance of gene silencing in Caenorhabditis elegans. Feng X, et al. J Genet Genomics, 2013 Apr 20. PMID 23618398
    3. Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. Burton NO, et al. Proc Natl Acad Sci U S A, 2011 Dec 6. PMID 22106253, Free PMC Article
    4. A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality. Buckley BA, et al. Nature, 2012 Sep 20. PMID 22810588, Free PMC Article
    5. A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulation. Burkhart KB, et al. PLoS Genet, 2011 Aug. PMID 21901112, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ANK_REP_REGION domain-containing protein
    NP_001343615.1
    • Confirmed by transcript evidence
    NP_001343616.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7646320..7654262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356928.3 → NP_001343615.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BI64

    2. NM_001356927.2 → NP_001343616.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYL3
    Nucleotide Protein
    Heading Accession and Version

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