dkf-2 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dkf-2
Official Full Name: Serine/threonine-protein kinase dkf-2
Primary source: WormBase:WBGene00012019
Locus tag: CELE_T25E12.4
See related: AllianceGenome:WB:WBGene00012019
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to bacterium; determination of adult lifespan; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of with a negative effect on protein import into nucleus. Located in cytoplasmic side of plasma membrane and cytosol. Part of serine/threonine protein kinase complex. Is expressed in intestine; neurons; pharynx; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human PRKD1 (protein kinase D1); PRKD2 (protein kinase D2); and PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dkf-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 21

Sequence:: Chromosome: V; NC_003283.11 (16747622..16788441)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DKF-2, a C. elegans PKD, regulates innate immunity
Title: Protein kinase D is an essential regulator of C. elegans innate immunity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25E12.4 (e-PCR)
- UniSTS:317607

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of serine/threonine protein kinase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Serine/threonine-protein kinase dkf-2

NP_001123022.1

Partially confirmed by transcript evidence

NP_001256724.1

Confirmed by transcript evidence

NP_001256725.1

Confirmed by transcript evidence

NP_001256726.1

Confirmed by transcript evidence

NP_001343593.1

Partially confirmed by transcript evidence

NP_507239.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16747622..16788441

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074838.7 → NP_507239.2 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507239.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B1V8I6, G5EEQ6, H9G324, H9G325, O45818, O62166, O62167

Conserved Domains (4) summary

cd01239
Location:618 → 728

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:766 → 1025

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20795
Location:319 → 374

C1_PKD_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the protein kinase D (PKD) family

cd20796
Location:473 → 525

C1_PKD_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD)
NM_001269796.3 → NP_001256725.1 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256725.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45818

Conserved Domains (5) summary

cd00029
Location:474 → 523

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:643 → 753

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:791 → 1050

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00069
Location:798 → 1051

Pkinase; Protein kinase domain

pfam00130
Location:326 → 371

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001269795.3 → NP_001256724.1 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256724.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45818

Conserved Domains (5) summary

cd00029
Location:472 → 521

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:616 → 726

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:764 → 1023

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00069
Location:771 → 1024

Pkinase; Protein kinase domain

pfam00130
Location:326 → 371

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001269797.3 → NP_001256726.1 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256726.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45818

Conserved Domains (5) summary

cd00029
Location:252 → 301

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:396 → 506

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:544 → 803

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00069
Location:551 → 804

Pkinase; Protein kinase domain

pfam00130
Location:104 → 149

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001129550.3 → NP_001123022.1 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001123022.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45818

Conserved Domains (5) summary

cd00029
Location:276 → 325

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:420 → 530

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:568 → 827

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00069
Location:575 → 828

Pkinase; Protein kinase domain

pfam00130
Location:128 → 173

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001356774.3 → NP_001343593.1 Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14082
Location:231 → 490

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D