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    swm-1 Serine protease inhibitor swm-1 [ Caenorhabditis elegans ]

    Gene ID: 182893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swm-1
    Official Full Name
    Serine protease inhibitor swm-1
    Primary source
    WormBase:WBGene00023417
    Locus tag
    CELE_C25E10.9
    See related
    AllianceGenome:WB:WBGene00023417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Is expressed in body wall musculature; coelomocyte; reproductive tract; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See swm-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (9054111..9054871, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TIL domain-containing protein Neighboring gene TIL domain-containing protein Neighboring gene TIL domain-containing protein Neighboring gene INSulin related Neighboring gene Prohormone-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sperm activation: time and tide wait for no sperm. Singson A. Curr Biol, 2006 Mar 7. PMID 16527731
    2. Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility. Chavez DR, et al. Development, 2018 Dec 18. PMID 30470702, Free PMC Article
    3. TRY-5 is a sperm-activating protease in Caenorhabditis elegans seminal fluid. Smith JR, et al. PLoS Genet, 2011 Nov. PMID 22125495, Free PMC Article
    4. Mutations in two independent pathways are sufficient to create hermaphroditic nematodes. Baldi C, et al. Science, 2009 Nov 13. PMID 19965511
    5. Male-specific roles of lincRNA in C. elegans fertility. Shabtai R, et al. Front Cell Dev Biol, 2023. PMID 37035238, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males.
      Title: Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Serine protease inhibitor swm-1
    NP_505346.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9054111..9054871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072945.4 → NP_505346.1  Serine protease inhibitor swm-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18158
      Conserved Domains (1) summary
      pfam01826
      Location:20 → 73
      TIL; Trypsin Inhibitor like cysteine rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18158.1

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