dxbp-1 DNA/RNA-binding protein Kin17 WH-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dxbp-1
Official Full Name: DNA/RNA-binding protein Kin17 WH-like domain-containing protein
Primary source: WormBase:WBGene00013128
Locus tag: CELE_Y52B11A.9
See related: AllianceGenome:WB:WBGene00013128
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable double-stranded DNA binding activity. Predicted to be involved in DNA damage response and DNA replication. Located in nucleolus. Is expressed widely. Orthologous to human KIN (Kin17 DNA and RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dxbp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (11034059..11038827, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.
Title: A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y52B11A.9 (e-PCR)
- UniSTS:319783

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleolus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA/RNA-binding protein Kin17 WH-like domain-containing protein

NP_492860.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11034059..11038827 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060459.6 → NP_492860.1 DNA/RNA-binding protein Kin17 WH-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492860.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XWF2

Conserved Domains (3) summary

cd13155
Location:352 → 403

KOW_KIN17; KOW_Kin17 is a RNA-binding motif

pfam10357
Location:55 → 169

Kin17_mid; Domain of Kin17 curved DNA-binding protein

pfam18131
Location:289 → 340

KN17_SH3; KN17 SH3-like C-terminal domain