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    rmh-2 RecQ-mediated genome instability protein 1 [ Caenorhabditis elegans ]

    Gene ID: 179383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rmh-2
    Official Full Name
    RecQ-mediated genome instability protein 1
    Primary source
    WormBase:WBGene00011576
    Locus tag
    CELE_T07C12.12
    See related
    AllianceGenome:WB:WBGene00011576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleotide binding activity. Involved in larval development. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nuclear body. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rmh-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (9927781..9930775, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Homeobox domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene DUF2040 domain-containing protein Neighboring gene pseudo Neighboring gene Serpentine Receptor, class J

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex. Velkova M, et al. PLoS Genet, 2021 Jul. PMID 34252074, Free PMC Article
    2. Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance. Jagut M, et al. PLoS Biol, 2016 Mar. PMID 27011106, Free PMC Article
    3. The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline. Dello Stritto MR, et al. Nucleic Acids Res, 2022 Jun 10. PMID 35639927, Free PMC Article
    4. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
    5. DNA topoisomerase 3 is required for efficient germ cell quality control. Dello Stritto MR, et al. J Cell Biol, 2021 Jun 7. PMID 33798260, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RecQ family helicase-topoisomerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RecQ-mediated genome instability protein 1
    NP_741607.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9927781..9930775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171521.9 → NP_741607.1  RecQ-mediated genome instability protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF82
      Conserved Domains (2) summary
      pfam08585
      Location:16 → 196
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:482 → 610
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold
    Nucleotide Protein
    Heading Accession and Version

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