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    rpa-4 RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186576, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpa-4
    Official Full Name
    RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00019079
    Locus tag
    CELE_F59A3.6
    See related
    AllianceGenome:WB:WBGene00019079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Orthologous to human RPA2 (replication protein A2) and RPA4 (replication protein A4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpa-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (5509470..5511689, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative MFS-type transporter C09D4.1 Neighboring gene Large ribosomal subunit protein uL24m Neighboring gene Zinc transporter ZIP11 Neighboring gene SPK domain-containing protein Neighboring gene MIF4G domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis. Hefel A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476370, Free PMC Article
    2. DNA double-strand break repair in Caenorhabditis elegans. Lemmens BB, et al. Chromosoma, 2011 Feb. PMID 21052706, Free PMC Article
    3. R-loop-induced irreparable DNA damage evades checkpoint detection in the C. elegans germline. Hicks T, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35871299, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
      Title: RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein
    NP_001300421.1
    • Confirmed by transcript evidence
    NP_001367475.1
    • Confirmed by transcript evidence
    NP_001368496.1
    • Partially confirmed by transcript evidence
    NP_001368500.1
    • Partially confirmed by transcript evidence
    NP_001379644.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5509470..5511689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392313.1 → NP_001379644.1  RPA_C domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91356
      Conserved Domains (1) summary
      cd04478
      Location:64 → 162
      RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...

    2. NM_001380260.1 → NP_001368496.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7G2
      Conserved Domains (1) summary
      cl09930
      Location:1 → 39
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    3. NM_001380261.1 → NP_001368500.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU77
      Conserved Domains (1) summary
      cl21533
      Location:71 → 111
      Cas8a1_I-A; CRISPR/Cas system-associated protein Cas8a1

    4. NM_001380262.1 → NP_001367475.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7G2
      Conserved Domains (1) summary
      cl09930
      Location:1 → 39
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    5. NM_001313492.3 → NP_001300421.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU77

    RNA

    1. NR_132558.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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