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    F46H5.7 AMPK1_CBM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F46H5.7
    Official Full Name
    AMPK1_CBM domain-containing protein
    Primary source
    WormBase:WBGene00018522
    Locus tag
    CELE_F46H5.7
    See related
    AllianceGenome:WB:WBGene00018522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F46H5.7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (7238666..7242983, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc finger protein syd-9 Neighboring gene ncRNA Neighboring gene putative arginine kinase F46H5.3 Neighboring gene ncRNA Neighboring gene C2 DOCK-type domain-containing protein Neighboring gene MATH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. Zheleva A, et al. PLoS Genet, 2019 Sep. PMID 31525188, Free PMC Article
    2. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article
    3. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    4. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
    5. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMPK1_CBM domain-containing protein
    NP_001360046.1
    • Confirmed by transcript evidence
    NP_741829.1
    • Confirmed by transcript evidence
    NP_741830.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7238666..7242983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373351.1 → NP_001360046.1  AMPK1_CBM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L049
      Conserved Domains (3) summary
      cd02859
      Location:499 → 577
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
      TIGR02169
      Location:109 → 444
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam18694
      Location:19 → 82
      TDP43_N; Transactive response DNA-binding protein N-terminal domain

    2. NM_171719.9 → NP_741829.1  AMPK1_CBM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L048
      Conserved Domains (3) summary
      cd02859
      Location:493 → 571
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
      pfam00261
      Location:174 → 396
      Tropomyosin; Tropomyosin
      cl23720
      Location:168 → 264
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_171958.8 → NP_741830.1  AMPK1_CBM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ42
      Conserved Domains (3) summary
      cd02859
      Location:496 → 574
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
      pfam00261
      Location:174 → 396
      Tropomyosin; Tropomyosin
      cl23720
      Location:168 → 264
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version

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