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    vps-24 Charged multivesicular body protein 3 [ Caenorhabditis elegans ]

    Gene ID: 173863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-24
    Official Full Name
    Charged multivesicular body protein 3
    Primary source
    WormBase:WBGene00020866
    Locus tag
    CELE_T27F7.1
    See related
    AllianceGenome:WB:WBGene00020866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Orthologous to human RNF103-CHMP3 (RNF103-CHMP3 readthrough) and CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-24 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (4994217..4995607)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene SUI1 domain-containing protein Neighboring gene Mannosyltransferase Neighboring gene Ribonuclease H1;Ribonuclease H1 N-terminal domain-containing protein Neighboring gene Conserved secreted protein Neighboring gene non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Approaches to Studying Caenorhabditis elegans ESCRT Functions In Vitro. Block S, et al. Methods Mol Biol, 2019. PMID 31250303, Free PMC Article
    2. The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation. Schuh AL, et al. Biochem J, 2015 Mar 15. PMID 25588614, Free PMC Article
    3. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    4. CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans. Roudier N, et al. Traffic, 2005 Aug. PMID 15998324
    5. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Samuelson AV, et al. Genes Dev, 2007 Nov 15. PMID 18006689, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Charged multivesicular body protein 3
    NP_494919.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4994217..4995607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062518.9 → NP_494919.1  Charged multivesicular body protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYK4
      Conserved Domains (1) summary
      cl21588
      Location:16 → 180
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version

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