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    ethe-1 Metallo-beta-lactamase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ethe-1
    Official Full Name
    Metallo-beta-lactamase domain-containing protein
    Primary source
    WormBase:WBGene00007886
    Locus tag
    CELE_C33A12.7
    See related
    AllianceGenome:WB:WBGene00007886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sulfur dioxygenase activity. Predicted to be involved in glutathione metabolic process and hydrogen sulfide metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in ethylmalonic encephalopathy. Orthologous to human ETHE1 (ETHE1 persulfide dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ethe-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (9506936..9508761, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase Neighboring gene pseudo Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene TFIP11 Neighboring gene DUF309 domain-containing protein;UPF0462 protein C4orf33 homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium. Romanelli-Credrez L, et al. Front Genet, 2020. PMID 32161616, Free PMC Article
    2. Lifespan and healthspan benefits of exogenous H(2)S in C. elegans are independent from effects downstream of eat-2 mutation. Ng LT, et al. NPJ Aging Mech Dis, 2020. PMID 32566245, Free PMC Article
    3. The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide. Budde MW, et al. Genetics, 2011 Oct. PMID 21840852, Free PMC Article
    4. Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38517909, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sulfur dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen sulfide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Metallo-beta-lactamase domain-containing protein
    NP_501684.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9506936..9508761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069283.7 → NP_501684.1  Metallo-beta-lactamase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17636
      Conserved Domains (1) summary
      PLN02962
      Location:10 → 234
      PLN02962; hydroxyacylglutathione hydrolase
    Nucleotide Protein
    Heading Accession and Version

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