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    cir-1 CBF1-interacting co-repressor CIR N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cir-1
    Official Full Name
    CBF1-interacting co-repressor CIR N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00018892
    Locus tag
    CELE_F55F8.4
    See related
    AllianceGenome:WB:WBGene00018892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription corepressor activity. Involved in oogenesis. Located in nucleus. Orthologous to human CIR1 (corepressor interacting with RBPJ, CIR1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cir-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5653828..5655857, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene ATP-dependent RNA helicase Neighboring gene Periodic tryptophan protein 2 homolog Neighboring gene Ribosome biogenesis protein WDR12 homolog Neighboring gene Mitochondrial fission factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1. Kasturi P, et al. Dev Biol, 2010 Aug 15. PMID 20478293
    2. The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway. Contreras-Cornejo H, et al. Cell Div, 2016. PMID 27708688, Free PMC Article
    3. Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis. Krüger AV, et al. Dev Biol, 2015 Feb 15. PMID 25446273
    4. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    5. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CBF1-interacting co-repressor CIR N-terminal domain-containing protein
    NP_491654.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5653828..5655857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059253.5 → NP_491654.1  CBF1-interacting co-repressor CIR N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBE3
      Conserved Domains (1) summary
      smart01083
      Location:13 → 49
      Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR
    Nucleotide Protein
    Heading Accession and Version

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