ubxn-1 UBX domain-containing protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubxn-1
Official Full Name: UBX domain-containing protein 1
Primary source: WormBase:WBGene00017733
Locus tag: CELE_F23C8.4
See related: AllianceGenome:WB:WBGene00017733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables K48-linked polyubiquitin modification-dependent protein binding activity. Involved in masculinization of hermaphroditic germ-line; positive regulation of protein catabolic process; and spermatogenesis. Acts upstream of or within IRE1-mediated unfolded protein response. Located in perinuclear region of cytoplasm. Is expressed in several structures, including gonad. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ubxn-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (2434002..2435691)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23C8.9 (e-PCR)
- UniSTS:321125

F23C8.4 (e-PCR)
- UniSTS:317367

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K48-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in masculinization of hermaphroditic germ-line	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UBX domain-containing protein 1

NP_490978.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2434002..2435691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058577.8 → NP_490978.1 UBX domain-containing protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490978.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TXH9

Conserved Domains (3) summary

cd01772
Location:219 → 297

SAKS1_UBX; SAKS1-like UBX domain

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily

cl26511
Location:86 → 197

Neuromodulin_N; Gap junction protein N-terminal region