U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rsd-6 Tudor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172621, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rsd-6
    Official Full Name
    Tudor domain-containing protein
    Primary source
    WormBase:WBGene00004684
    Locus tag
    CELE_F16D3.2
    See related
    AllianceGenome:WB:WBGene00004684
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in P granule organization; piRNA processing; and spermatogenesis. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rsd-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (8358254..8363858, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase Neighboring gene SAC domain-containing protein Neighboring gene putative cytochrome P450 CYP36A1 Neighboring gene Tubulin alpha chain Neighboring gene Tubulin-specific chaperone D Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene PQ-loop repeat-containing protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transgene-Assisted Genetic Screen Identifies rsd-6 and Novel Genes as Key Components of Antiviral RNA Interference in Caenorhabditis elegans. Long T, et al. J Virol, 2018 Sep 1. PMID 29950414, Free PMC Article
    2. Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations. Sakaguchi A, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25258416, Free PMC Article
    3. The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments. Han W, et al. Genetics, 2008 Apr. PMID 18430922, Free PMC Article
    4. The DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans. Yang H, et al. Curr Biol, 2014 Apr 14. PMID 24684930, Free PMC Article
    5. Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs. Henricson A, et al. BMC Genomics, 2004 Nov 8. PMID 15533247, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This genetic screen also identified rsd-6, a gene that maintains genome integrity under unfavorable conditions, as a key regulator of worm antiviral silencing, demonstrating an interplay between antiviral immunity and genome integrity maintenance.
      Title: Transgene-Assisted Genetic Screen Identifies rsd-6 and Novel Genes as Key Components of Antiviral RNA Interference in Caenorhabditis elegans.
    2. RSD-2 and RSD-6 promote germ cell immortality at stressful temperatures by maintaining transgenerational epigenetic inheritance of endogenous siRNA populations that promote genome silencing.
      Title: Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations.
    3. The ultimate functions of rsd-2 and rsd-6 in systemic RNA interference are remarkably complex and environmentally responsive.
      Title: The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Tudor domain-containing protein
    NP_492269.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8358254..8363858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059868.10 → NP_492269.2  Tudor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492269.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19491, Q19492
      Conserved Domains (2) summary
      PHA03307
      Location:82 → 319
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00567
      Location:520 → 626
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools