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    pygl-1 Alpha-1,4 glucan phosphorylase [ Caenorhabditis elegans ]

    Gene ID: 178777, updated on 9-Dec-2024

    Summary

    Official Symbol
    pygl-1
    Official Full Name
    Alpha-1,4 glucan phosphorylase
    Primary source
    WormBase:WBGene00020696
    Locus tag
    CELE_T22F3.3
    See related
    AllianceGenome:WB:WBGene00020696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycogen phosphorylase activity and pyridoxal phosphate binding activity. Predicted to be involved in glycogen catabolic process. Predicted to be active in cytoplasm. Is expressed in germ line. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease V; glycogen storage disease VI; and lactic acidosis. Orthologous to several human genes including PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See pygl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (3579023..3585042)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Transposase Neighboring gene Ground-like domain-containing protein Neighboring gene tRNA-Pro Neighboring gene tRNA-Pro Neighboring gene Large ribosomal subunit protein uL5A Neighboring gene USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase 36 Neighboring gene tRNA-Pro

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity  
    enables glycogen phosphorylase activity  
    enables glycogen phosphorylase activity  
    enables glycosyltransferase activity  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in glycogen catabolic process  
    involved_in glycogen metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    Alpha-1,4 glucan phosphorylase
    NP_001309657.1
    • Confirmed by transcript evidence
    NP_001317772.1
    • Confirmed by transcript evidence
    NP_001379943.1
    • Confirmed by transcript evidence
    NP_504007.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3579023..3585042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071606.5 → NP_504007.1  Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5U1
      Conserved Domains (2) summary
      cd04300
      Location:63 → 865
      GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...
      TIGR02093
      Location:66 → 865
      P_ylase; glycogen/starch/alpha-glucan phosphorylases
    2. NM_001392495.1 → NP_001379943.1  Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NC1
      Conserved Domains (1) summary
      cd04300
      Location:27 → 829
      GT35_Glycogen_Phosphorylase; glycogen phosphorylase and similar proteins
    3. NM_001330794.3 → NP_001317772.1  Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCL1
    4. NM_001322539.3 → NP_001309657.1  Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MDC6
      Conserved Domains (1) summary
      cl10013
      Location:1 → 231
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
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