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    Y105E8B.7 Protein AF-9 homolog [ Caenorhabditis elegans ]

    Gene ID: 190914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y105E8B.7
    Official Full Name
    Protein AF-9 homolog
    Primary source
    WormBase:WBGene00013692
    Locus tag
    CELE_Y105E8B.7
    See related
    AllianceGenome:WB:WBGene00013692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit) and MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y105E8B.7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (14642714..14646601)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e Neighboring gene ncRNA Neighboring gene Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein Neighboring gene BTB and MATH domain-containing protein 40 Neighboring gene Serine/threonine-protein kinase RIO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx. McKay JP, et al. Genetics, 2004 Jan. PMID 15020415, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Allele-specific genetic interactions between eat-2 and eat-18 suggest that EAT-18 interacts physically with the EAT-2 receptor.
      Title: eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein AF-9 homolog
    NP_493542.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14642714..14646601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061141.5 → NP_493542.2  Protein AF-9 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493542.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NF15
      Conserved Domains (1) summary
      pfam03366
      Location:24 → 105
      YEATS; YEATS family
    Nucleotide Protein
    Heading Accession and Version

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