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    F42H10.3 LIM and SH3 domain protein F42H10.3 [ Caenorhabditis elegans ]

    Gene ID: 185685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F42H10.3
    Official Full Name
    LIM and SH3 domain protein F42H10.3
    Primary source
    WormBase:WBGene00018367
    Locus tag
    CELE_F42H10.3
    See related
    AllianceGenome:WB:WBGene00018367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Located in cell junction and striated muscle dense body. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F42H10.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (8484153..8488396)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene HAT C-terminal dimerization domain-containing protein;Zinc finger BED domain-containing protein 39 Neighboring gene Putative esterase F42H10.6 Neighboring gene ncRNA Neighboring gene Splicing factor ESS-2 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    LIM and SH3 domain protein F42H10.3
    NP_001263722.1
    • Confirmed by transcript evidence
    NP_498874.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8484153..8488396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276793.4 → NP_001263722.1  LIM and SH3 domain protein F42H10.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E951
      Conserved Domains (4) summary
      smart00227
      Location:102 → 129
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 59
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11789
      Location:255 → 308
      SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
      pfam00880
      Location:70 → 96
      Nebulin; Nebulin repeat

    2. NM_066473.5 → NP_498874.2  LIM and SH3 domain protein F42H10.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498874.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34416, P34417, P34421, Q6AHR7
      Conserved Domains (4) summary
      smart00227
      Location:102 → 129
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 59
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11789
      Location:271 → 324
      SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
      pfam00880
      Location:70 → 96
      Nebulin; Nebulin repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34416.3

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