doxa-1 Dual oxidase maturation factor 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: doxa-1
Official Full Name: Dual oxidase maturation factor 1
Primary source: WormBase:WBGene00015519
Locus tag: CELE_C06E1.3
See related: AllianceGenome:WB:WBGene00015519
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in gonad; hypodermis; terminal bulb; and vulva. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to human DUOXA1 (dual oxidase maturation factor 1) and DUOXA2 (dual oxidase maturation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide.
Title: The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_498886.2

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