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    eco-1 N-acetyltransferase ESCO2 [ Caenorhabditis elegans ]

    Gene ID: 176046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eco-1
    Official Full Name
    N-acetyltransferase ESCO2
    Primary source
    WormBase:WBGene00017269
    Locus tag
    CELE_F08F8.4
    See related
    AllianceGenome:WB:WBGene00017269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptide-lysine-N-acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to several human genes including ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eco-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (7357663..7359095, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Nuclear transcription factor Y subunit Neighboring gene 3-hydroxy-3-methylglutaryl coenzyme A reductase Neighboring gene PB1 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells. Yu Z, et al. Nat Struct Mol Biol, 2023 Apr. PMID 36879153, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyltransferase ESCO2
    NP_498625.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7357663..7359095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066224.5 → NP_498625.1  N-acetyltransferase ESCO2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19206
      Conserved Domains (2) summary
      pfam13878
      Location:86 → 125
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      cl17182
      Location:239 → 299
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version

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