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    set-17 Histone-lysine N-methyltransferase set-17 [ Caenorhabditis elegans ]

    Gene ID: 174425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-17
    Official Full Name
    Histone-lysine N-methyltransferase set-17
    Primary source
    WormBase:WBGene00011887
    Locus tag
    CELE_T21B10.5
    See related
    AllianceGenome:WB:WBGene00011887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K4 methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; germ line; intestine; primary spermatocyte; and vulval muscle. Orthologous to human PRDM7 (PR/SET domain 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-17 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8939054..8940488, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Enolase Neighboring gene THO complex subunit 2 Neighboring gene Uncharacterized protein Neighboring gene ZP domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility. Engert CG, et al. PLoS Genet, 2018 Apr. PMID 29702639, Free PMC Article
    2. Photoaged Polystyrene Nanoplastics Result in Transgenerational Reproductive Toxicity Associated with the Methylation of Histone H3K4 and H3K9 in Caenorhabditis elegans. Chen H, et al. Environ Sci Technol, 2023 Dec 5. PMID 37934861
    3. Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Greer EL, et al. Cell Res, 2016 Feb. PMID 26691751, Free PMC Article
    4. The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans. Araoi S, et al. J Biochem, 2018 May 1. PMID 29361115
    5. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Greer EL, et al. Cell Rep, 2014 Apr 10. PMID 24685137, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the germline-expressed C. elegans protein SET-17, which has a SET domain similar to that of the PRDM9 and PRDM7 SET-domain proteins, promotes fertility by regulating gene expression in primary spermatocytes
      Title: A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone-lysine N-methyltransferase set-17
    NP_001317778.1
    • Partially confirmed by transcript evidence
    NP_001368599.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8939054..8940488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330955.2 → NP_001317778.1  Histone-lysine N-methyltransferase set-17 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A163UT06, A0A168H266
      Conserved Domains (2) summary
      cd19193
      Location:128 → 255
      PR-SET_PRDM7_9; PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins
      cl22851
      Location:82 → 113
      PHD_SF; PHD finger superfamily

    2. NM_001381544.1 → NP_001368599.1  Histone-lysine N-methyltransferase set-17 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd19193
      Location:116 → 243
      PR-SET_PRDM7_9; PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins
      cl22851
      Location:70 → 101
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A163UT06.1

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