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    flp-8 FMRF-Like Peptide [ Caenorhabditis elegans ]

    Gene ID: 181583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flp-8
    Official Full Name
    FMRF-Like Peptide
    Primary source
    WormBase:WBGene00001451
    Locus tag
    CELE_F31F6.4
    See related
    AllianceGenome:WB:WBGene00001451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of turning behavior involved in mating. Predicted to be located in extracellular region. Is expressed in PVM; head; somatic nervous system; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flp-8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (14881419..14882267)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein quiver Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling via the FLP-14/FRPR-19 neuropeptide pathway sustains nociceptive response to repeated noxious stimuli in C. elegans. Marques F, et al. PLoS Genet, 2021 Nov. PMID 34748554, Free PMC Article
    2. Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans. Szczepańska A, et al. Nat Commun, 2024 Mar 28. PMID 38548742, Free PMC Article
    3. Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans. Kim K, et al. J Comp Neurol, 2004 Aug 2. PMID 15236235
    4. Changes in locomotory behavior and cAMP produced in Ascaris suum by neuropeptides from Ascaris suum or Caenorhabditis elegans. Reinitz CA, et al. Mol Biochem Parasitol, 2000 Nov. PMID 11087928
    5. Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine, and FMRFamide-like neuropeptides. Rogers CM, et al. J Neurobiol, 2001 Nov 15. PMID 11745661

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. flp-8 is required for the sensory transduction involved in male turning behavior.
      Title: FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of turning behavior involved in mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FMRF-Like Peptide
    NP_741934.1
    • Product from WormBase gene class flp;
      Confirmed by transcript evidence
    NP_741935.1
    • Product from WormBase gene class flp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14881419..14882267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171805.4 → NP_741935.1  FMRF-Like Peptide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGN5

    2. NM_171804.8 → NP_741934.1  FMRF-Like Peptide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQF5
    Nucleotide Protein
    Heading Accession and Version

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