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    • Showing Current items.

    such-1 Suppressor of spindle checkpoint defect 1 [ Caenorhabditis elegans ]

    Gene ID: 176583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    such-1
    Official Full Name
    Suppressor of spindle checkpoint defect 1
    Primary source
    WormBase:WBGene00013443
    Locus tag
    CELE_Y66D12A.17
    See related
    AllianceGenome:WB:WBGene00013443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Is expressed in germ line; head neurons; sperm; and vulval precursor cell. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See such-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (11512862..11523759, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase spe-6 Neighboring gene ArgoN domain-containing protein Neighboring gene DUF1604 domain-containing protein;SMAP domain-containing protein;Spen family transcriptional repressor Neighboring gene General transcription and DNA repair factor IIH helicase/translocase subunit XPB Neighboring gene Carrier domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans. Tarailo M, et al. Genetics, 2007 Apr. PMID 17237515, Free PMC Article
    2. Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Stein KK, et al. Genetics, 2010 Dec. PMID 20944012, Free PMC Article
    3. Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans. Bezler A, et al. Genetics, 2010 Dec. PMID 20944014, Free PMC Article
    4. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Green RA, et al. Cell, 2011 Apr 29. PMID 21529718, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Suppressor of spindle checkpoint defect 1
    NP_499485.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11512862..11523759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067084.7 → NP_499485.2  Suppressor of spindle checkpoint defect 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499485.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q00
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95Q00.2

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