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    feh-1 Amyloid beta A4 precursor protein-binding family B member 2-like;Protein Fe65 homolog [ Caenorhabditis elegans ]

    Gene ID: 175373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    feh-1
    Official Full Name
    Amyloid beta A4 precursor protein-binding family B member 2-like;Protein Fe65 homolog
    Primary source
    WormBase:WBGene00001410
    Locus tag
    CELE_Y54F10AM.2
    See related
    AllianceGenome:WB:WBGene00001410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables amyloid-beta binding activity. Involved in embryo development; feeding behavior; and nematode larval development. Located in actin filament. Is expressed in nerve ring; pharynx; tail neurons; and ventral cord neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to several human genes including APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See feh-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (2549920..2560684)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Neighboring gene Homeobox protein cut-like ceh-44 Neighboring gene Protein CASP Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BTB domain-containing protein Neighboring gene Nuclear receptor domain-containing protein Neighboring gene Mitochondrial genome maintenance exonuclease 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping. Zambrano N, et al. J Cell Sci, 2002 Apr 1. PMID 11896189
    2. A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse. Napolitano F, et al. Neurochem Res, 2008 Dec. PMID 18401706
    3. Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes. Bimonte M, et al. Eur J Neurosci, 2004 Sep. PMID 15355315
    4. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Niwa R, et al. Dev Biol, 2008 Mar 15. PMID 18262516, Free PMC Article
    5. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. observed similar up-regulation of Nme1 and Nme2 genes, both at the transcript and the protein levels, in the brain of Fe65 knock-out mice, thus highlighting the occurrence of evolutionary conserved mechanisms of Nme expression in nematodes and mammals
      Title: A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse.
    2. These results indicate a target of the regulatory mechanisms based on the Fe65-APP complex that could be relevant for the pathogenesis of Alzheimer's disease.
      Title: Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Amyloid beta A4 precursor protein-binding family B member 2-like;Protein Fe65 homolog
    NP_001022906.1
    • Confirmed by transcript evidence
    NP_001360128.1
    • Confirmed by transcript evidence
    NP_001380183.1
    • Confirmed by transcript evidence
    NP_497578.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2549920..2560684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065177.7 → NP_497578.4  Protein Fe65 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0Q7, H2L0Q8, Q8WQE2, Q9BKZ9
      Conserved Domains (3) summary
      cd01271
      Location:487 → 611
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:329 → 464
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:235 → 264
      WW; WW domain

    2. NM_001027735.5 → NP_001022906.1  Protein Fe65 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BKZ9
      Conserved Domains (3) summary
      cd01271
      Location:487 → 611
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:329 → 464
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:235 → 264
      WW; WW domain

    3. NM_001393297.1 → NP_001380183.1  Amyloid beta A4 precursor protein-binding family B member 2-like [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARY0
      Conserved Domains (3) summary
      cd01271
      Location:376 → 500
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:218 → 353
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:124 → 153
      WW; WW domain

    4. NM_001373858.3 → NP_001360128.1  Protein Fe65 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd01271
      Location:376 → 500
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:218 → 353
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:124 → 153
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BKZ9.2

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