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    tpa-1 Protein kinase C-like 1 [ Caenorhabditis elegans ]

    Gene ID: 176825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tpa-1
    Official Full Name
    Protein kinase C-like 1
    Primary source
    WormBase:WBGene00006599
    Locus tag
    CELE_B0545.1
    See related
    AllianceGenome:WB:WBGene00006599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; peptidyl-serine phosphorylation; and positive regulation of antimicrobial peptide production. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Used to study Down syndrome. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta) and PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tpa-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (91980..110819)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SCP domain-containing protein Neighboring gene HAT C-terminal dimerization domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans. Tabuse Y, et al. Science, 1989 Mar 31. PMID 2538925
    2. The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar to Ca(2+)-independent protein kinase Cs: evidence by complete genomic and complementary DNA sequences of the tpa-1 gene. Sano T, et al. J Mol Biol, 1995 Aug 25. PMID 7658466
    3. Origin, properties, and regulated expression of multiple mRNAs encoded by the protein kinase C1 gene of Caenorhabditis elegans. Land M, et al. J Biol Chem, 1994 May 20. PMID 8182089
    4. A gene involved in action of tumor promoters is identified and mapped in Caenorhabditis elegans. Tabuse Y, et al. Carcinogenesis, 1983. PMID 6861282
    5. Molecular evidence for the direct involvement of a protein kinase C in developmental and behavioural susceptibility to tumour-promoting phorbol esters in Caenorhabditis elegans. Tabuse Y, et al. Biochem J, 1995 Nov 15. PMID 7492337, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
      Title: A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
    2. In a screen for mutants that fail to express nlp-29 following fungal infection, alleles of tpa-1 were isolated, homologous to the mammalian protein kinase C (PKC) delta.
      Title: Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase C-like 1
    NP_001359809.1
    • Confirmed by transcript evidence
    NP_001379590.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      91980..110819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392238.1 → NP_001379590.1  Protein kinase C-like 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34722
      Conserved Domains (3) summary
      cd05592
      Location:379 → 700
      STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
      cd20834
      Location:159 → 219
      C1_nPKC_theta-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins
      cd20837
      Location:238 → 287
      C1_nPKC_theta-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins

    2. NM_001372684.2 → NP_001359809.1  Protein kinase C-like 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd05592
      Location:242 → 563
      STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
      pfam00130
      Location:101 → 151
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34722.2

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