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    his-3 Histone H2A [ Caenorhabditis elegans ]

    Gene ID: 180073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    his-3
    Official Full Name
    Histone H2A
    Primary source
    WormBase:WBGene00001877
    Locus tag
    CELE_T10C6.12
    See related
    AllianceGenome:WB:WBGene00001877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See his-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_003283.11 (16040808..16041191)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Histone H2B 2 Neighboring gene ncRNA Neighboring gene Histone H3 Neighboring gene Histone H4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis. Zedek F, et al. PLoS One, 2012. PMID 22291967, Free PMC Article
    2. The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity. Takahashi Y, et al. J Recept Signal Transduct Res, 2011 Apr. PMID 21385054
    3. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. Bessler JB, et al. PLoS Genet, 2010 Jan 22. PMID 20107519, Free PMC Article
    4. Differential chromatin marking of introns and expressed exons by H3K36me3. Kolasinska-Zwierz P, et al. Nat Genet, 2009 Mar. PMID 19182803, Free PMC Article
    5. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger K, et al. Nature, 2007 Oct 11. PMID 17713478

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular characterization of NAP1 chaperoning activity toward histones H2A/H2B has been reported.
      Title: Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B.
    2. Although CENP-C did not show any signs of positive selection, positive selection has been detected in the case of CENH3.
      Title: Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis.
    3. H3K9me2 and H3K9me3 are highly autonomous chromatin modifications, functioning independently in the germ line.
      Title: Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.
    4. H3K36me3 exon marking in chromatin provides a dynamic link between transcription and splicing.
      Title: Differential chromatin marking of introns and expressed exons by H3K36me3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone H2A
    NP_507032.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16040808..16041191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074631.5 → NP_507032.1  Histone H2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09588, Q7JKF5
      Conserved Domains (1) summary
      PTZ00017
      Location:18 → 127
      PTZ00017; histone H2A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09588.2

    Gene LinkOut

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