ftt-2 14-3-3 domain-containing protein;14-3-3-like protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ftt-2
Official Full Name: 14-3-3 domain-containing protein;14-3-3-like protein 2
Primary source: WormBase:WBGene00001502
Locus tag: CELE_F52D10.3
See related: AllianceGenome:WB:WBGene00001502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor binding activity. Involved in cytoplasmic sequestering of protein; dauer larval development; and negative regulation of protein import into nucleus. Located in cytoplasm and nucleus. Is expressed in several structures, including AB; C; E; EMS; and gonad. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ftt-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (11603708..11605419, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FTT-2 binds to DAF-16 in C. elegans and regulates DAF-16 by sequestering it in the cytoplasm
Title: The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans.
results suggest that C. elegans 14-3-3 proteins, par-5 and FTT-2 can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO
Title: C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
C. elegans 14-3-3 protein is identified as a SIR-2.1 binding partner; required for the life-span extension conferred by extra copies of sir-2.1.
Title: C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52D10.3 (e-PCR)
- UniSTS:319382

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic sequestering of protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 14-3-3 domain-containing protein;14-3-3-like protein 2

NP_001337315.1

Confirmed by transcript evidence

NP_509939.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11603708..11605419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001350351.5 → NP_001337315.1 14-3-3 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

W6EKY2

Conserved Domains (1) summary

cl02098
Location:4 → 233

14-3-3; 14-3-3 domain
NM_077538.9 → NP_509939.1 14-3-3-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509939.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20655

UniProtKB/TrEMBL

W6E8Z9

Conserved Domains (1) summary

cl02098
Location:4 → 233

14-3-3; 14-3-3 domain