Tpbpa trophoblast specific protein alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpbpaprovided by MGI
Official Full Name: trophoblast specific protein alphaprovided by MGI
Primary source: MGI:MGI:98795
See related: Ensembl:ENSMUSG00000033834 AllianceGenome:MGI:98795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tb1; Tb-1; Tpbp; b2b1247Clo
Summary: Acts upstream of or within JNK cascade and cellular response to organic cyclic compound. Predicted to be located in extracellular region. Is expressed in extraembryonic component and placenta. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 3122.9) See more
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Genomic context

Location:: 13 B2; 13 32.57 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61086306..61089750, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (60938492..60941936, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta.
Title: Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta.
A widespread interstitial invasion in the decidua basalis by glycogen trophoblast cells was detected after E12.5. These cells did not express Plf, but rather expressed the spongiotrophoblast-specific gene Tpbp.
Title: Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta.

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General gene information

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Markers

RH128922 (e-PCR)
- UniSTS:212230

Tpbpa (e-PCR), detects polymorphism
- UniSTS:532246

Tpbpa (e-PCR), detects polymorphism
- UniSTS:144663

NoName (e-PCR)
- UniSTS:548411

AV033951 (e-PCR)
- UniSTS:165878

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trophoblast-specific protein alpha

Names: Mutant line 1247; clone 4311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009411.5 → NP_033437.2 trophoblast-specific protein alpha precursor

Status: VALIDATED

Source sequence(s)

AK005454, AK028071

Consensus CDS

CCDS36693.1

UniProtKB/Swiss-Prot

P13438

UniProtKB/TrEMBL

Q9CPR0, Q9D6B1

Related

ENSMUSP00000021885.7, ENSMUST00000021885.8