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    ECA3 endoplasmic reticulum-type calcium-transporting ATPase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837550, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ECA3
    Official Full Name
    endoplasmic reticulum-type calcium-transporting ATPase 3
    Primary source
    TAIR:AT1G10130
    Locus tag
    AT1G10130
    See related
    Araport:AT1G10130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA ER-TYPE CA2+-ATPASE 3; ATECA3; endoplasmic reticulum-type calcium-transporting ATPase 3; T27I1.16; T27I1_16
    Summary
    Encodes a golgi localized P2A-type Ca2+ ATPase involved in Mn nutrition and homeostasis.
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    Genomic context

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    See ECA3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    34
    Sequence:
    Chromosome: 1; NC_003070.9 (3310930..3322269)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene ncRNA Neighboring gene Uncharacterized conserved protein UCP031279 Neighboring gene Carbohydrate-binding protein Neighboring gene phloem protein 2-A10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ECA3, a Golgi-localized P2A-type ATPase, plays a crucial role in manganese nutrition in Arabidopsis. Mills RF, et al. Plant Physiol, 2008 Jan. PMID 18024560, Free PMC Article
    2. A distinct endosomal Ca2+/Mn2+ pump affects root growth through the secretory process. Li X, et al. Plant Physiol, 2008 Aug. PMID 18567829, Free PMC Article
    3. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
    4. Two additional type IIA Ca(2+)-ATPases are expressed in Arabidopsis thaliana: evidence that type IIA sub-groups exist. Pittman JK, et al. Gene, 1999 Aug 5. PMID 10433975
    5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtECA3 supports Ca(2+)-stimulated root growth and the detoxification of high Mn(2+).
      Title: A distinct endosomal Ca2+/Mn2+ pump affects root growth through the secretory process.
    2. It was proposed that ECA3 is important for manganese and calcium homeostasis, possibly functioning in the transport of these ions into the Golgi.
      Title: ECA3, a Golgi-localized P2A-type ATPase, plays a crucial role in manganese nutrition in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100887.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type manganese transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    endoplasmic reticulum-type calcium-transporting ATPase 3
    NP_563860.1
    • endoplasmic reticulum-type calcium-transporting ATPase 3 (ECA3); FUNCTIONS IN: manganese-transporting ATPase activity, calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: manganese ion transport, calcium ion transport, root development, manganese ion homeostasis; LOCATED IN: endomembrane system, Golgi apparatus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting (InterPro:IPR005782), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: endomembrane-type CA-ATPase 4 (TAIR:AT1G07670.1); Has 52019 Blast hits to 33942 proteins in 3233 species: Archae - 1100; Bacteria - 36533; Metazoa - 4334; Fungi - 2931; Plants - 2474; Viruses - 3; Other Eukaryotes - 4644 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3310930..3322269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100887.3 → NP_563860.1  endoplasmic reticulum-type calcium-transporting ATPase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563860.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WP80, Q6DQH3, Q9SAV5, Q9SMX2, Q9SWS8, Q9SY55
      UniProtKB/TrEMBL
      A0A654E9M6
      Conserved Domains (1) summary
      cd02083
      Location:5 → 975
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SY55.3

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