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    GPCR G protein coupled receptor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841725, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPCR
    Official Full Name
    G protein coupled receptor
    Primary source
    TAIR:AT1G52920
    Locus tag
    AT1G52920
    See related
    Araport:AT1G52920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14G24.19; F14G24_19; G protein coupled receptor; G-PROTEIN COUPLED RECEPTOR 2; GCR2
    Summary
    Encodes a plasma membrane#Aeilocalized ABA receptor, which interacts with the Galphabetagamma complex. It has been postulated that the binding of ABA to GCR2 results in the release of the G protein and dissociation of the heterotrimeric complex into Galpha and the Gbetagamma dimer to activate downstream ABA effectors and to trigger the ABA responses.
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    Genomic context

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    See GPCR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (19709275..19711081, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fiber (DUF1218) Neighboring gene ncRNA Neighboring gene Ribosomal RNA processing Brix domain protein Neighboring gene purple acid phosphatase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reevaluation of abscisic acid-binding assays shows that G-Protein-Coupled Receptor2 does not bind abscisic Acid. Risk JM, et al. Plant Physiol, 2009 May. PMID 19286934, Free PMC Article
    2. The GCR2 gene family is not required for ABA control of seed germination and early seedling development in Arabidopsis. Guo J, et al. PLoS One, 2008 Aug 20. PMID 18714360, Free PMC Article
    3. Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis. Gao Y, et al. Plant J, 2007 Dec. PMID 17894782
    4. A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Liu X, et al. Science, 2007 Mar 23. PMID 17347412
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G-Protein-Coupled Receptor2 does not bind abscisic Acid.
      Title: Reevaluation of abscisic acid-binding assays shows that G-Protein-Coupled Receptor2 does not bind abscisic Acid.
    2. ompelling genetic evidence that GCR2 is unlikely to act as a receptor for Abscisic acid in the context of either seed germination or early seedling development.
      Title: The GCR2 gene family is not required for ABA control of seed germination and early seedling development in Arabidopsis.
    3. GCR2 is not an ABA-signaling GPCR in seed germination and early seedling development. [GCR2]
      Title: Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis.
    4. the G protein-coupled receptor, GCR2, interacts with the G protein alpha subunit GPA1 to mediate all known abscisic acid (ABA) responses in Arabidopsis; results demonstrate that GCR2 is a plasma membrane ABA receptor
      Title: A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104170.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables abscisic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within maintenance of seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein coupled receptor
    NP_175700.2
    • G protein coupled receptor (GPCR); CONTAINS InterPro DOMAIN/s: LanC-like protein, eukaryotic (InterPro:IPR020464), Six-hairpin glycosidase-like (InterPro:IPR008928), Lanthionine synthetase C-like (InterPro:IPR007822); BEST Arabidopsis thaliana protein match is: GCR2-like 2 (TAIR:AT2G20770.1); Has 681 Blast hits to 670 proteins in 211 species: Archae - 0; Bacteria - 184; Metazoa - 280; Fungi - 66; Plants - 112; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19709275..19711081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104170.3 → NP_175700.2  G protein coupled receptor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175700.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IEM5, Q9C929
      UniProtKB/TrEMBL
      A0A654EHY8, A0A7G2E456
      Conserved Domains (1) summary
      cd04794
      Location:75 → 406
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IEM5.1

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