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    ORP2A OSBP(oxysterol binding protein)-related protein 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828349, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ORP2A
    Official Full Name
    OSBP(oxysterol binding protein)-related protein 2A
    Primary source
    TAIR:AT4G22540
    Locus tag
    AT4G22540
    See related
    Araport:AT4G22540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F7K2.120; F7K2_120; OSBP(oxysterol binding protein)-related protein 2A
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    Genomic context

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    See ORP2A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (11860409..11866475, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene miscRNA Neighboring gene Phosphatidic acid phosphatase (PAP2) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation. Yu Q, et al. Plant Physiol, 2023 Aug 3. PMID 37073508
    2. Screening for in planta protein-protein interactions combining bimolecular fluorescence complementation with flow cytometry. Berendzen KW, et al. Plant Methods, 2012 Jul 12. PMID 22789293, Free PMC Article
    3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
    4. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
      Title: Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036621.3
    NM_001203871.1
    NM_001341552.1
    NM_001341553.1
    NM_118380.3
    NM_202863.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    OSBP(oxysterol binding protein)-related protein 2A
    NP_001031698.1
    • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001190800.1
    • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1).
    NP_567662.1
    • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Oxysterol-binding protein (InterPro:IPR000648), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974592.1
    • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11860409..11866475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118380.3 → NP_567662.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WMK9, Q56W69, Q940Y1, Q9SUW5
      UniProtKB/TrEMBL
      A0A178UYT2, A0A5S9XUT6
      Conserved Domains (2) summary
      cd13294
      Location:53 → 185
      PH_ORP_plant; Plant Oxysterol binding protein related protein Pleckstrin homology (PH) domain
      pfam01237
      Location:344 → 696
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001341552.1 → NP_001328217.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WMK9, Q56W69, Q940Y1, Q9SUW5
      UniProtKB/TrEMBL
      A0A178UYT2, A0A5S9XUT6
      Conserved Domains (2) summary
      cd13294
      Location:53 → 185
      PH_ORP_plant; Plant Oxysterol binding protein related protein Pleckstrin homology (PH) domain
      pfam01237
      Location:344 → 696
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001341553.1 → NP_001328218.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F570
      Conserved Domains (1) summary
      pfam01237
      Location:133 → 485
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_001203871.1 → NP_001190800.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F570
      Conserved Domains (1) summary
      pfam01237
      Location:133 → 485
      Oxysterol_BP; Oxysterol-binding protein

    5. NM_202863.3 → NP_974592.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F570
      Conserved Domains (1) summary
      pfam01237
      Location:133 → 485
      Oxysterol_BP; Oxysterol-binding protein

    6. NM_001036621.3 → NP_001031698.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F570
      Conserved Domains (1) summary
      pfam01237
      Location:133 → 485
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940Y1.1

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