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    TIC21 translocon at inner membrane of chloroplasts 21 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816018, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIC21
    Official Full Name
    translocon at inner membrane of chloroplasts 21
    Primary source
    TAIR:AT2G15290
    Locus tag
    AT2G15290
    See related
    Araport:AT2G15290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTic21; ATTIC21; CHLOROPLAST IMPORT APPARATUS 5; CIA5; F27O10.6; F27O10_6; PERMEASE IN CHLOROPLASTS 1; PIC1; translocon at inner membrane of chloroplasts 21; TRANSLOCON AT INNER MEMBRANE OF CHLOROPLASTS 21
    Summary
    Encodes a protein located in the chloroplast inner envelope. The study of mutant defective in the gene product suggests that the protein is involved in the translocation of protein across the envelope membrane into the chloroplast stroma.
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    Genomic context

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    See TIC21 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (6642300..6644055, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene PRKR-interacting protein Neighboring gene miscRNA Neighboring gene Reticulon family protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron. Duy D, et al. Plant Physiol, 2011 Apr. PMID 21343424, Free PMC Article
    2. A 1-megadalton translocation complex containing Tic20 and Tic21 mediates chloroplast protein import at the inner envelope membrane. Kikuchi S, et al. Plant Cell, 2009 Jun. PMID 19531596, Free PMC Article
    3. Tic21 is an essential translocon component for protein translocation across the chloroplast inner envelope membrane. Teng YS, et al. Plant Cell, 2006 Sep. PMID 16891400, Free PMC Article
    4. PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport. Duy D, et al. Plant Cell, 2007 Mar. PMID 17337631, Free PMC Article
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. By mediating iron uptake and sequestering processes in plastids, PIC1 is crucial for plant growth and development in general and in particular for fruit maturation.
      Title: The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron.
    2. PIC1 functions in iron transport across the inner envelope of chloroplasts and hence in cellular metal homeostasis. [PIC1] [PERMEASE INCHLOROPLASTS1]
      Title: PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport.
    3. Tic21 functions as part of the inner membrane protein-conducting channel and may be more important for later stages of leaf development. [Tic21] [CIA5]
      Title: Tic21 is an essential translocon component for protein translocation across the chloroplast inner envelope membrane.
    Submit: New GeneRIF Correction

    General gene information

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    NM_127089.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Tic complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Tic complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    translocon at inner membrane of chloroplasts 21
    NP_565372.1
    • translocon at inner membrane of chloroplasts 21 (TIC21); FUNCTIONS IN: copper uptake transmembrane transporter activity, protein homodimerization activity, iron ion transmembrane transporter activity; INVOLVED IN: protein import into chloroplast stroma, cellular metal ion homeostasis; LOCATED IN: chloroplast, chloroplast inner membrane, chloroplast envelope, Tic complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3611 (InterPro:IPR022051); Has 312 Blast hits to 312 proteins in 84 species: Archae - 0; Bacteria - 154; Metazoa - 0; Fungi - 0; Plants - 61; Viruses - 0; Other Eukaryotes - 97 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      6642300..6644055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127089.4 → NP_565372.1  translocon at inner membrane of chloroplasts 21 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SHU7
      UniProtKB/TrEMBL
      A0A654ET01, A0A7G2E8I6
      Conserved Domains (1) summary
      pfam12263
      Location:107 → 282
      DUF3611; Protein of unknown function (DUF3611)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SHU7.1

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