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    ADC1 arginine decarboxylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816149, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADC1
    Official Full Name
    arginine decarboxylase 1
    Primary source
    TAIR:AT2G16500
    Locus tag
    AT2G16500
    See related
    Araport:AT2G16500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARGDC; ARGDC1; ARGININE DECARBOXYLASE; arginine decarboxylase 1; F1P15.12; F1P15_12; SPE1
    Summary
    encodes a arginine decarboxylase (ADC), a rate-limiting enzyme that catalyzes the first step of polyamine (PA) biosynthesis via ADC pathway in Arabidopsis thaliana. Arabidopsis genome has two ADC paralogs, ADC1 and ADC2. Double mutant analysis showed that ADC genes are essential for the production of PA, and are required for normal seed development. Promoter region of ADC1 contains 742-bp AT-rich transposable element, called AtATE, that belongs to the MITE families of repetitive elements.
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    Genomic context

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    See ADC1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (7150514..7153430, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene GW repeat- and PHD finger-containing protein NERD Neighboring gene XH domain-containing protein Neighboring gene maternally expressed family protein Neighboring gene ATPase, F0/V0 complex, subunit C protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2. Maruri-López I, et al. Biochem Biophys Res Commun, 2017 Mar 11. PMID 28109885
    2. Simultaneous Silencing of Two Arginine Decarboxylase Genes Alters Development in Arabidopsis. Sánchez-Rangel D, et al. Front Plant Sci, 2016. PMID 27014322, Free PMC Article
    3. Role of Arginine decarboxylase (ADC) in Arabidopsis thaliana defence against the pathogenic bacterium Pseudomonas viridiflava. Rossi FR, et al. Plant Biol (Stuttg), 2015 Jul. PMID 25409942
    4. Putrescine is involved in Arabidopsis freezing tolerance and cold acclimation by regulating abscisic acid levels in response to low temperature. Cuevas JC, et al. Plant Physiol, 2008 Oct. PMID 18701673, Free PMC Article
    5. Arabidopsis ADC genes involved in polyamine biosynthesis are essential for seed development. Urano K, et al. FEBS Lett, 2005 Feb 28. PMID 15733873

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study reveals that both ADC proteins are located in the same cell compartments, and they are able to form protein interaction complexes with each other.
      Title: Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2.
    2. ADC2 had a major contribution of to total arginine decarboxylase (ADC) activity and the specific induction of ADC1 in response to infection.
      Title: Role of Arginine decarboxylase (ADC) in Arabidopsis thaliana defence against the pathogenic bacterium Pseudomonas viridiflava.
    3. Arginine decarboxylase genes are required for production of polyamines that are essential for normal seed development in Arabidopsis
      Title: Arabidopsis ADC genes involved in polyamine biosynthesis are essential for seed development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_127204.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arginine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine decarboxylase activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polyamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginine decarboxylase 1
    NP_179243.1
    • arginine decarboxylase 1 (ADC1); CONTAINS InterPro DOMAIN/s: Orn/DAP/Arg decarboxylase 2, C-terminal (InterPro:IPR022643), Orn/DAP/Arg decarboxylase 2, conserved site (InterPro:IPR022657), Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (InterPro:IPR022653), Ornithine/DAP/Arg decarboxylase (InterPro:IPR000183), Arginine decarboxylase (InterPro:IPR002985), Orn/DAP/Arg decarboxylase 2, N-terminal (InterPro:IPR022644); BEST Arabidopsis thaliana protein match is: arginine decarboxylase 2 (TAIR:AT4G34710.2); Has 7460 Blast hits to 7389 proteins in 2069 species: Archae - 108; Bacteria - 5016; Metazoa - 91; Fungi - 35; Plants - 637; Viruses - 2; Other Eukaryotes - 1571 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7150514..7153430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127204.3 → NP_179243.1  arginine decarboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179243.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38938, Q9SI64
      UniProtKB/TrEMBL
      A0A5S9WYQ1, A0A654ETA4, A0A7G2EAJ1
      Conserved Domains (1) summary
      PLN02439
      Location:97 → 663
      PLN02439; arginine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SI64.1

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