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    SUVH3 histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843641, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUVH3
    Official Full Name
    histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3-like protein
    Primary source
    TAIR:AT1G73100
    Locus tag
    AT1G73100
    See related
    Araport:AT1G73100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3N23.30; F3N23_30; SDG19; SET DOMAIN PROTEIN 19; SU(VAR)3-9 homolog 3
    Summary
    Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain.
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    Genomic context

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    See SUVH3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (27491184..27494182)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene PEP1 receptor 1 Neighboring gene WD repeat protein Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene F-box/RNI superfamily protein Neighboring gene mucin Neighboring gene trichome birefringence-like protein (DUF828)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intron-regulated expression of SUVH3, an Arabidopsis Su(var)3-9 homologue. Casas-Mollano JA, et al. J Exp Bot, 2006. PMID 16928780
    2. A DNA methylation reader complex that enhances gene transcription. Harris CJ, et al. Science, 2018 Dec 7. PMID 30523112, Free PMC Article
    3. A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes. Zhao QQ, et al. J Integr Plant Biol, 2019 Feb. PMID 30589221
    4. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes. Baumbusch LO, et al. Nucleic Acids Res, 2001 Nov 1. PMID 11691919, Free PMC Article
    5. The TOPLESS interactome: a framework for gene repression in Arabidopsis. Causier B, et al. Plant Physiol, 2012 Jan. PMID 22065421, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An intron located in the 5' UTR is a key regulator of strong and constitutive SUVH3 expression.
      Title: Intron-regulated expression of SUVH3, an Arabidopsis Su(var)3-9 homologue.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105968.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3-like protein
    NP_565056.1
    • SU(VAR)3-9 homolog 3 (SUVH3); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728), Post-SET domain (InterPro:IPR003616); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 1 (TAIR:AT5G04940.2); Has 4599 Blast hits to 4427 proteins in 402 species: Archae - 0; Bacteria - 285; Metazoa - 2284; Fungi - 494; Plants - 1115; Viruses - 0; Other Eukaryotes - 421 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27491184..27494182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105968.3 → NP_565056.1  histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565056.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5P4, Q9SSL7
      UniProtKB/TrEMBL
      A0A178WF93, A0A5S9WTX3
      Conserved Domains (2) summary
      smart00466
      Location:203 → 359
      SRA; SET and RING finger associated domain
      cl40432
      Location:410 → 638
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5P4.2

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