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    ROS4 Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820727, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROS4
    Official Full Name
    Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein
    Primary source
    TAIR:AT3G14980
    Locus tag
    AT3G14980
    See related
    Araport:AT3G14980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    IDM1; increased DNA methylation 1; REPRESSOR OF SILENCING 4
    Summary
    IDM1 is a histone H3 acetyltransferase that is capable of recognizing methylated DNA through its MBD domain and recognizing unmethylated histone H3K4 through its PHD domain. It negatively regulates DNA demethylation, preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences.
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    Genomic context

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    See ROS4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (5039812..5045525, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Galactosyltransferase family protein Neighboring gene RING/U-box superfamily protein Neighboring gene uncharacterized protein Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene cobalt ion binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Qian W, et al. Science, 2012 Jun 15. PMID 22700931, Free PMC Article
    2. Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis. Qian W, et al. Mol Cell, 2014 Aug 7. PMID 25002145, Free PMC Article
    3. Antisilencing role of the RNA-directed DNA methylation pathway and a histone acetyltransferase in Arabidopsis. Li X, et al. Proc Natl Acad Sci U S A, 2012 Jul 10. PMID 22733760, Free PMC Article
    4. REPRESSOR OF SILENCING5 Encodes a Member of the Small Heat Shock Protein Family and Is Required for DNA Demethylation in Arabidopsis. Zhao Y, et al. Plant Cell, 2014 Jun. PMID 24920332, Free PMC Article
    5. Regulation of Active DNA Demethylation by a Methyl-CpG-Binding Domain Protein in Arabidopsis thaliana. Li Q, et al. PLoS Genet, 2015 May. PMID 25933434, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338143.1
    NM_001338144.1
    NM_001338145.1
    NM_001338146.1
    NM_001338147.1
    NM_112360.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded methylated DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H3K18 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene silencing by siRNA-directed DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein
    NP_188116.1
    • Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein; FUNCTIONS IN: DNA binding, zinc ion binding, N-acetyltransferase activity; INVOLVED IN: regulation of transcription, DNA-dependent, metabolic process; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase (InterPro:IPR000182), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Acyl-CoA N-acyltransferase (InterPro:IPR016181), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein (TAIR:AT1G05380.2); Has 4644 Blast hits to 3909 proteins in 217 species: Archae - 1; Bacteria - 6; Metazoa - 3256; Fungi - 362; Plants - 697; Viruses - 0; Other Eukaryotes - 322 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5039812..5045525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112360.3 → NP_188116.1  Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IXE7, Q9LKA7
      UniProtKB/TrEMBL
      A0A178VFZ3, A0A5S9XC73, A0A7G2EKT7
      Conserved Domains (4) summary
      cd15539
      Location:729 → 768
      PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
      pfam16135
      Location:651 → 702
      Jas; TPL-binding domain in jasmonate signalling
      cl00110
      Location:256 → 283
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
      cl17182
      Location:915 → 1001
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. NM_001338144.1 → NP_001326246.1  Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LNP2, A0A7G2EKT7

    3. NM_001338143.1 → NP_001326245.1  Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IXE7, Q9LKA7
      UniProtKB/TrEMBL
      A0A178VFZ3, A0A5S9XC73, A0A7G2EKT7
      Conserved Domains (4) summary
      cd15539
      Location:729 → 768
      PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
      pfam16135
      Location:651 → 702
      Jas; TPL-binding domain in jasmonate signalling
      cl00110
      Location:256 → 283
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
      cl17182
      Location:915 → 1001
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    4. NM_001338145.1 → NP_001326243.1  Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LNN9

    5. NM_001338146.1 → NP_001326244.1  Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LNP0, A0A7G2EKT7

    6. NM_001338147.1 → NP_001326242.1  Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IXE7, Q9LKA7
      UniProtKB/TrEMBL
      A0A178VFZ3, A0A5S9XC73, A0A7G2EKT7
      Conserved Domains (4) summary
      cd15539
      Location:729 → 768
      PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
      pfam16135
      Location:651 → 702
      Jas; TPL-binding domain in jasmonate signalling
      cl00110
      Location:256 → 283
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
      cl17182
      Location:915 → 1001
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IXE7.1

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