DEG5 DEGP protease 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DEG5
Official Full Name: DEGP protease 5
Primary source: TAIR:AT4G18370
Locus tag: AT4G18370
See related: Araport:AT4G18370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DEGP protease 5; DEGP PROTEASE 5; DEGP5; degradation of periplasmic proteins 5; F28J12.30; F28J12_30; HHOA; PROTEASE HHOA PRECUSOR
Summary: Encodes DEG5. Forms a hexamer with DEG8 in the thylakoid lumen. Involved in the cleavage of photodamaged D2 protein of photosystem II (PSII).
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Genomic context

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See DEG5 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (10148951..10151218)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work suggests that differences in protein abundance and proteolytic activity underlie the differential importance of Deg1 and Deg5-Deg8 protease complexes observed in vivo.
Title: Differential Roles of the Thylakoid Lumenal Deg Protease Homologs in Chloroplast Proteostasis.
Deg5 protein is unique in that it contains no PDZ domain and the trimeric structure of Deg5 (S266A) reveals a novel catalytic triad conformation.
Title: The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases.
These data demonstrate in vivo cooperative degradation of D1, in which Deg cleavage assists FtsH processive degradation under photoinhibitory conditions.
Title: Cooperative D1 degradation in the photosystem II repair mediated by chloroplastic proteases in Arabidopsis.
crystals of Deg5 belonged to the monoclinic space group C2, with unit-cell parameters a = 109.1, b = 126.0, c = 83.3 A, beta = 102.9 degrees , and contained three molecules in the asymmetric unit
Title: Expression, purification, crystallization and preliminary X-ray diffraction analysis of Deg5 from Arabidopsis thaliana.
Our results demonstrate that Deg5 is of seminal importance for normal plant development and degradation of PsbF which occurs following brief wounding.
Title: Involvement of Deg5 protease in wounding-related disposal of PsbF apoprotein.
DEG5 and DEG8 have a synergistic function in the primary cleavage of the CD loop of the PSII reaction center protein D1. [DEG5]
Title: Formation of DEG5 and DEG8 complexes and their involvement in the degradation of photodamaged photosystem II reaction center D1 protein in Arabidopsis.

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General gene information

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NM_001341278.1

Supported by ESTs:

NM_001341279.1

Supported by ESTs:

NM_117947.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within photosystem II repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast thylakoid lumen	HDA more info	PubMed
located_in chloroplast thylakoid lumen	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in thylakoid	HDA more info	PubMed
located_in thylakoid lumen	HDA more info	PubMed

General protein information

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Preferred Names: DEGP protease 5

NP_567552.2

DEGP protease 5 (DEG5); FUNCTIONS IN: serine-type peptidase activity, catalytic activity, serine-type endopeptidase activity; INVOLVED IN: photosystem II repair, proteolysis; LOCATED IN: thylakoid, thylakoid lumen, chloroplast thylakoid lumen, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254); BEST Arabidopsis thaliana protein match is: DegP protease 1 (TAIR:AT3G27925.1); Has 15121 Blast hits to 15118 proteins in 2570 species: Archae - 102; Bacteria - 10211; Metazoa - 307; Fungi - 110; Plants - 358; Viruses - 2; Other Eukaryotes - 4031 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

10148951..10151218

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117947.5 → NP_567552.2 DEGP protease 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567552.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O49507, Q93ZW5, Q9SEL7

UniProtKB/TrEMBL

A0A178V353, A0A5S9XTN2

Conserved Domains (1) summary

pfam13365
Location:131 → 280

Trypsin_2; Trypsin-like peptidase domain
NM_001341278.1 → NP_001328913.1 DEGP protease 5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V353, A0A1P8B643, A0A5S9XTN2
NM_001341279.1 → NP_001328914.1 DEGP protease 5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B644