U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    BIGYIN Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824876, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    BIGYIN
    Official Full Name
    Tetratricopeptide repeat (TPR)-like superfamily protein
    Primary source
    TAIR:AT3G57090
    Locus tag
    AT3G57090
    See related
    Araport:AT3G57090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FIS1A; FISSION 1A
    Summary
    Encodes a protein with similarity to yeast FIS proteins. These membrane anchored proteins bind DRP proteins and function during organelle division. FIS1B is expressed ubiquitously and appears to be involved in peroxisome division.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BIGYIN in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (21128396..21131089)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Glutaredoxin family protein Neighboring gene uncharacterized protein Neighboring gene Eukaryotic rpb5 RNA polymerase subunit family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transmembrane protein, putative (DUF677)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. FISSION1A, an Arabidopsis tail-anchored protein, is localized to three subcellular compartments. Ruberti C, et al. Mol Plant, 2014 Aug. PMID 24658461
    2. BIGYIN, an orthologue of human and yeast FIS1 genes functions in the control of mitochondrial size and number in Arabidopsis thaliana. Scott I, et al. J Exp Bot, 2006. PMID 16510519
    3. FISSION1A and FISSION1B proteins mediate the fission of peroxisomes and mitochondria in Arabidopsis. Zhang XC, et al. Mol Plant, 2008 Nov. PMID 19825601
    4. Two small protein families, DYNAMIN-RELATED PROTEIN3 and FISSION1, are required for peroxisome fission in Arabidopsis. Zhang X, et al. Plant J, 2009 Jan. PMID 18785999
    5. The Arabidopsis chloroplast division protein DYNAMIN-RELATED PROTEIN5B also mediates peroxisome division. Zhang X, et al. Plant Cell, 2010 Feb. PMID 20179140, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. subcellular localization of FISSION1A protein
      Title: FISSION1A, an Arabidopsis tail-anchored protein, is localized to three subcellular compartments.
    2. FIS1A and FIS1B play rate-limiting and partially overlapping roles in promoting the fission of peroxisomes and mitochondria. [FISSION1A] [FIS1A]
      Title: FISSION1A and FISSION1B proteins mediate the fission of peroxisomes and mitochondria in Arabidopsis.
    3. DRP3 and FIS1 protein families contribute to peroxisome fission in Arabidopsis, and support the view that DRP and FIS1 orthologs are common components of the peroxisomal and mitochondrial division machineries. [FIS1A]
      Title: Two small protein families, DYNAMIN-RELATED PROTEIN3 and FISSION1, are required for peroxisome fission in Arabidopsis.
    4. BIGYIN is an Arabidopsis FIS orthologue and is part of the Arabidopsis mitochondrial division apparatus. [BIGYIN]
      Title: BIGYIN, an orthologue of human and yeast FIS1 genes functions in the control of mitochondrial size and number in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_115568.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Tetratricopeptide repeat (TPR)-like superfamily protein
    NP_567044.1
    • BIGYIN; FUNCTIONS IN: binding; INVOLVED IN: peroxisome fission, mitochondrion organization; LOCATED IN: mitochondrion, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide repeat 11 Fission 1 protein (InterPro:IPR016543), Tetratricopeptide-like helical (InterPro:IPR011990); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT5G12390.1); Has 347 Blast hits to 347 proteins in 156 species: Archae - 0; Bacteria - 0; Metazoa - 100; Fungi - 148; Plants - 92; Viruses - 0; Other Eukaryotes - 7 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21128396..21131089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339841.1 → NP_001327069.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1J1
      UniProtKB/TrEMBL
      A0A5S9XM87, A0A654FGL0
      Conserved Domains (1) summary
      cd12212
      Location:23 → 141
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    2. NM_115568.4 → NP_567044.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1J1
      UniProtKB/TrEMBL
      A0A5S9XM87, A0A654FGL0
      Conserved Domains (1) summary
      cd12212
      Location:23 → 141
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1J1.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools