U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CYCA1;2 CYCLIN A1;2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844075, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CYCA1;2
    Official Full Name
    CYCLIN A1;2
    Primary source
    TAIR:AT1G77390
    Locus tag
    AT1G77390
    See related
    Araport:AT1G77390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYCA1; CYCLIN A1; CYCLIN A1;2; DYP; F2P24.10; F2P24_10; TAM; TARDY ASYNCHRONOUS MEIOSIS
    Summary
    Encodes a core cell cycle gene involved in meiosis II during microsporogenesis. Recessive mutants exhibit delayed and asynchronous meiosis in pollen mother cell populations and uncoordinated nuclear division and cytokinesis resulting in dyad microspores.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CYCA1;2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (29081654..29084285, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene extensin-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The role for CYCLIN A1;2/TARDY ASYNCHRONOUS MEIOSIS in differentiated cells in Arabidopsis. Jha AK, et al. Plant Mol Biol, 2014 May. PMID 24430502
    2. Polyploidy-associated genomic instability in Arabidopsis thaliana. Wang Y, et al. Genesis, 2010 Apr. PMID 20143347
    3. Progression through meiosis I and meiosis II in Arabidopsis anthers is regulated by an A-type cyclin predominately expressed in prophase I. Wang Y, et al. Plant Physiol, 2004 Dec. PMID 15557098, Free PMC Article
    4. The Arabidopsis gene tardy asynchronous meiosis is required for the normal pace and synchrony of cell division during male meiosis. Magnard JL, et al. Plant Physiol, 2001 Nov. PMID 11706195, Free PMC Article
    5. The cyclin-A CYCA1;2/TAM is required for the meiosis I to meiosis II transition and cooperates with OSD1 for the prophase to first meiotic division transition. d'Erfurth I, et al. PLoS Genet, 2010 Jun 17. PMID 20585549, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that cellular homeostasis of the CYCA1;2/TAM protein is linked to the control of nuclear sizes in trichomes and guard cells
      Title: The role for CYCLIN A1;2/TARDY ASYNCHRONOUS MEIOSIS in differentiated cells in Arabidopsis.
    2. We thus propose that a functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC/C inhibitor.
      Title: OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM.
    3. Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2)
      Title: Meiotic progression in Arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM.
    4. series of CYCA1;2 mutants failed to enter meiosis II and thus produced diploid spores and functional diploid gametes.
      Title: The cyclin-A CYCA1;2/TAM is required for the meiosis I to meiosis II transition and cooperates with OSD1 for the prophase to first meiotic division transition.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_106388.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CYCLIN A1;2
    NP_177863.2
    • CYCLIN A1;2 (CYCA1;2); CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin, A/B/D/E (InterPro:IPR014400), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: Cyclin A1;1 (TAIR:AT1G44110.1); Has 4576 Blast hits to 4572 proteins in 373 species: Archae - 0; Bacteria - 0; Metazoa - 2076; Fungi - 561; Plants - 1184; Viruses - 37; Other Eukaryotes - 718 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29081654..29084285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106388.4 → NP_177863.2  CYCLIN A1;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177863.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FVX0
      UniProtKB/TrEMBL
      A0A178WDV8, A0A5S9WV88
      Conserved Domains (2) summary
      cd20506
      Location:310 → 424
      CYCLIN_AtCycA-like_rpt2; second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins
      cd20562
      Location:171 → 306
      CYCLIN_AtCycA_like_rpt1; first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FVX0.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools