U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Rexo2 RNA exonuclease 2 [ Mus musculus (house mouse) ]

    Gene ID: 104444, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rexo2provided by MGI
    Official Full Name
    RNA exonuclease 2provided by MGI
    Primary source
    MGI:MGI:1888981
    See related
    Ensembl:ENSMUSG00000032026 AllianceGenome:MGI:1888981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfn; Rex2; Smfn; 1810038D15Rik
    Summary
    Predicted to enable 3'-5'-DNA exonuclease activity; 3'-5'-RNA exonuclease activity; and magnesium ion binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 86.0), liver E14 (RPKM 25.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rexo2 in Genome Data Viewer
    Location:
    9 A5.3; 9 26.42 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48379812..48391911, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48468512..48480611, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39335 Neighboring gene predicted gene 8884 Neighboring gene predicted gene, 39334 Neighboring gene STARR-seq mESC enhancer starr_24068 Neighboring gene STARR-positive B cell enhancer ABC_E3826 Neighboring gene RNA binding motif protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E9759 Neighboring gene predicted gene 5617

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity PubMed 
    enables 3'-5' exonuclease activity  
    enables 3'-5'-DNA exonuclease activity  
    enables 3'-5'-DNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables nucleic acid binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    oligoribonuclease, mitochondrial
    Names
    REX2, RNA exonuclease 2 homolog
    small fragment nuclease

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357501.2NP_001344430.1  oligoribonuclease, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC160992
      UniProtKB/TrEMBL
      Q3T9B4
      Conserved Domains (1) summary
      cd06135
      Location:46187
      Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
    2. NM_001357503.1NP_001344432.1  oligoribonuclease, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1.
      Source sequence(s)
      AC160992
      Consensus CDS
      CCDS90558.1
      UniProtKB/TrEMBL
      A0A1L1SS70, Q8BJ91
      Related
      ENSMUSP00000149784.2, ENSMUST00000217037.2
      Conserved Domains (1) summary
      cl10012
      Location:39121
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    3. NM_001357505.1NP_001344434.1  oligoribonuclease, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC160992
      Consensus CDS
      CCDS90557.1
      UniProtKB/TrEMBL
      A0A1L1SQJ5, Q8BJ91
      Related
      ENSMUSP00000149074.2, ENSMUST00000216470.2
      Conserved Domains (1) summary
      cl10012
      Location:39103
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    4. NM_024233.4NP_077195.2  oligoribonuclease, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_077195.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI839882, AK007731
      Consensus CDS
      CCDS23154.1
      UniProtKB/Swiss-Prot
      Q9D8S4
      UniProtKB/TrEMBL
      Q3T9B4
      Related
      ENSMUSP00000034524.4, ENSMUST00000034524.5
      Conserved Domains (1) summary
      cd06135
      Location:43215
      Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      48379812..48391911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.