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    Wls wntless WNT ligand secretion mediator [ Mus musculus (house mouse) ]

    Gene ID: 68151, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Wlsprovided by MGI
    Official Full Name
    wntless WNT ligand secretion mediatorprovided by MGI
    Primary source
    MGI:MGI:1915401
    See related
    Ensembl:ENSMUSG00000028173 AllianceGenome:MGI:1915401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EVI; Gpr177; 5031439A09Rik
    Summary
    Enables Wnt-protein binding activity. Involved in several processes, including brain development; cementum mineralization; and exocrine pancreas development. Acts upstream of or within Wnt protein secretion. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skin. Used to study Zaki syndrome. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 41.9), limb E14.5 (RPKM 30.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wls in Genome Data Viewer
    Location:
    3 H4; 3 82.65 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (159545287..159644302)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (159839650..159938666)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:159158158-159158459 Neighboring gene DEP domain containing 1a Neighboring gene retinal pigment epithelium 65 Neighboring gene STARR-seq mESC enhancer starr_09398 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:159503248-159503357 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) pseudogene Neighboring gene calponin 2 pseudogene Neighboring gene predicted gene, 23941

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnt signaling regulates pulp volume and dentin thickness. Lim WH, et al. J Bone Miner Res, 2014 Apr. PMID 23996396, Free PMC Article
    2. Wntless regulates dentin apposition and root elongation in the mandibular molar. Bae CH, et al. J Dent Res, 2015 Mar. PMID 25595365, Free PMC Article
    3. Gpr177-mediated Wnt Signaling is Required for Fungiform Placode Initiation. Zhu X, et al. J Dent Res, 2014 Jun. PMID 24736288
    4. Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models. Gao G, et al. Biochem Biophys Res Commun, 2019 Nov 19. PMID 31547988, Free PMC Article
    5. Selective deletion of WLS in peritubular myoid cells does not affect spermatogenesis or fertility in mice. Wang YQ, et al. Mol Reprod Dev, 2018 Jul. PMID 29693774

    See all (166) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
      Title: GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
    2. Epithelial Wntless regulates postnatal alveologenesis.
      Title: Epithelial Wntless regulates postnatal alveologenesis.
    3. Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration.
      Title: Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration.
    4. The function of Wls in ovarian development.
      Title: The function of Wls in ovarian development.
    5. Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.
      Title: Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.
    6. Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility.
      Title: Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility.
    7. Data show that epithelial Wntless was required for the growth and differentiation of small intestinal organoids but not in live animals.
      Title: Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models.
    8. Deletion of WLS in peritubular myoid cells is not essential for male fertility in mice.
      Title: Selective deletion of WLS in peritubular myoid cells does not affect spermatogenesis or fertility in mice.
    9. Data show that Shh-Cre-mediated deletion of Wntless, the Wnt cargo protein, in mouse posterior limb mesenchyme causes bone syndactyly of the 3rd and 4th digits, resembling the human Malik-Percin type . Wntless(Shh-Cre) limbs displayed altered expression of hedgehog pathway genes and impaired noncanonical Wnt signaling activity.
      Title: Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly.
    10. WLS role in the principal cells of the caput epididymidis during sperm maturation
      Title: Role of WNT signaling in epididymal sperm maturation.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mu-type opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mu-type opioid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Wnt protein secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cementum mineralization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein wntless homolog
    Names
    G protein-coupled receptor 177
    integral membrane protein GPR177
    protein evenness interrupted homolog
    wntless homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356349.1 → NP_001343278.1  protein wntless homolog isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC121906, AC225719, AK019886, BQ179316
      Conserved Domains (1) summary
      pfam06664
      Location:78 → 396
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    2. NM_001356350.1 → NP_001343279.1  protein wntless homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121906, AC175245, AC225719, AK044810
      Consensus CDS
      CCDS38684.1
      UniProtKB/Swiss-Prot
      Q6DID7, Q8CE42, Q9D2B7
      Related
      ENSMUSP00000143475.2, ENSMUST00000198878.2
      Conserved Domains (1) summary
      pfam06664
      Location:178 → 496
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    3. NM_026582.5 → NP_080858.3  protein wntless homolog isoform 1

      See identical proteins and their annotated locations for NP_080858.3

      Status: VALIDATED

      Source sequence(s)
      AC121906, AC225719, BC075615
      Consensus CDS
      CCDS38684.1
      UniProtKB/Swiss-Prot
      Q6DID7, Q8CE42, Q9D2B7
      Related
      ENSMUSP00000067898.6, ENSMUST00000068952.10
      Conserved Domains (1) summary
      pfam06664
      Location:178 → 496
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      159545287..159644302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DID7.1 GenPept UniProtKB/Swiss-Prot:Q6DID7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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