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    pyya peptide YYa [ Danio rerio (zebrafish) ]

    Gene ID: 30211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pyyaprovided by ZNC
    Official Full Name
    peptide YYaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-71
    See related
    Ensembl:ENSDARG00000053449 AllianceGenome:ZFIN:ZDB-GENE-980526-71
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pyy; zgc:194161; zgc:194175
    Summary
    Enables type 2 neuropeptide Y receptor binding activity. Predicted to be involved in feeding behavior and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to human PYY (peptide YY). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pyya in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (33340939..33344780)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (33209225..33213066)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, alpha b Neighboring gene heat shock protein, alpha-crystallin-related, 9 Neighboring gene si:dkey-283b1.6 Neighboring gene MAGUK p55 scaffold protein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish. Mathieu M, et al. Ann N Y Acad Sci, 2005 Apr. PMID 15891072
    2. Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. Larsson TA, et al. Peptides, 2006 Jun. PMID 16359756
    3. Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Torres-Hernández BA, et al. Psychopharmacology (Berl), 2016 Jul. PMID 27165438, Free PMC Article
    4. Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties. Fällmar H, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Dec. PMID 21855645
    5. Cloning and characterization of a zebrafish Y2 receptor. Fredriksson R, et al. Regul Pept, 2006 Jan 15. PMID 16257457

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties
      Title: Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.
    2. Developmental expression of zYb and zYc receptors suggests a role for peptide YY (PYY) in organogenesis.
      Title: Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide Y receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide Y receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables type 2 neuropeptide Y receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables type 2 neuropeptide Y receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptide YY-A
    Names
    peptide YY

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164371.1 → NP_001157843.1  peptide YY-A precursor

      See identical proteins and their annotated locations for NP_001157843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CABZ01012959, EH440265
      UniProtKB/Swiss-Prot
      B3DGK4, Q9I8P2
      Related
      ENSDARP00000108040.2, ENSDART00000128786.3
      Conserved Domains (1) summary
      pfam00159
      Location:30 → 64
      Hormone_3; Pancreatic hormone peptide

    2. NM_131016.2 → NP_571091.1  peptide YY-A precursor

      See identical proteins and their annotated locations for NP_571091.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC162436, CABZ01012959, EH440265
      UniProtKB/Swiss-Prot
      B3DGK4, Q9I8P2
      Related
      ENSDARP00000152843.1, ENSDART00000186352.1
      Conserved Domains (1) summary
      pfam00159
      Location:30 → 64
      Hormone_3; Pancreatic hormone peptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      33340939..33344780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I8P2.1 GenPept UniProtKB/Swiss-Prot:Q9I8P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.