mmp9 matrix metallopeptidase 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mmp9provided by ZNC
Official Full Name: matrix metallopeptidase 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2132
See related: Ensembl:ENSDARG00000042816 AllianceGenome:ZFIN:ZDB-GENE-040426-2132
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZFMMP-9; fj05a08; zgc:64165; wu:fb02g06; wu:fb07b05; wu:fi98c09; wu:fj05a08
Summary: Predicted to enable metalloendopeptidase activity. Involved in positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; female organism; hematopoietic cell; hematopoietic system; and muscle. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (24281525..24295947)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (24260286..24274708)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that MMP9 and MMP13 might play a key role in the inflammatory phase of heart regeneration in zebrafish, by mediating leukocyte recruitment via the activation of chemokines, in particular, CXCL8.
Title: Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration.
Mmp9 is dispensable for Hematopoietic stem cells budding, and is required for proper colonization of secondary niches.
Title: Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization.
The findings of this study suggest that Mmp-9 is a protective molecule against infection by Listeria monocytogenes by engaging in migration of zebrafish macrophages to the site of infection via a non-proteolytic role.
Title: Matrix metalloproteinase-9 plays a role in protecting zebrafish from lethal infection with Listeria monocytogenes by enhancing macrophage migration.
elevated beta-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment.
Title: Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production.
Mmp9 regulates both acute and chronic tissue damage and plays an essential role in collagen reorganization during wound repair.
Title: Matrix metalloproteinase 9 modulates collagen matrices and wound repair.
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13.
Title: Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos.
study identified mechanism by which mycobacteria induce granulomas: ESAT-6 induced MMP9 in epithelial cells neighboring infected macrophages; MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation & bacterial growth
Title: Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium.
expression and activity of MMP-2 and MMP-9 in the embryonic zebrafish.
Title: Glucocorticoids alter craniofacial development and increase expression and activity of matrix metalloproteinases in developing zebrafish (Danio rerio).
From 24h post fertilization, mmp9 expression was detected in a population of circulating white blood cells.
Title: Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fk34b11.y1 (e-PCR)
- UniSTS:200862

fj93e10.y1 (e-PCR)
- UniSTS:200369

fj93f08.y1 (e-PCR)
- UniSTS:200373

fb02g06.x1 (e-PCR)
- UniSTS:202681

AW174507 (e-PCR)
- UniSTS:205811

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen fibril organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelium development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within growth plate cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of granuloma formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: matrix metalloproteinase-9

Names: gelatinase B; matrix metalloproteinase 9

NP_998288.1

EC 3.4.24.35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213123.1 → NP_998288.1 matrix metalloproteinase-9 precursor

See identical proteins and their annotated locations for NP_998288.1

Status: PROVISIONAL

Source sequence(s)

BC053292

UniProtKB/TrEMBL

Q7T317

Related

ENSDARP00000062844.4, ENSDART00000062845.5

Conserved Domains (4) summary

smart00059
Location:340 → 388

FN2; Fibronectin type 2 domain

cd00094
Location:489 → 674

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:116 → 444

Peptidase_M10; Matrixin

pfam01471
Location:37 → 95

PG_binding_1; Putative peptidoglycan binding domain