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    lzts2b leucine zipper, putative tumor suppressor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 100005471, updated on 9-Dec-2024

    Summary

    Official Symbol
    lzts2bprovided by ZNC
    Official Full Name
    leucine zipper, putative tumor suppressor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9587
    See related
    Ensembl:ENSDARG00000077207 AllianceGenome:ZFIN:ZDB-GENE-030131-9587
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj90d02; wu:fj90d02
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and cell division. Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See lzts2b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47698751..47743001)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (47853062..47864728)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496857 Neighboring gene hematopoietically expressed homeobox Neighboring gene PDZ domain containing 7b Neighboring gene uncharacterized LOC110440159 Neighboring gene selenoprotein U1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spindle midzone assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine zipper putative tumor suppressor 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      47698751..47743001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358600.3XP_017214089.1  leucine zipper putative tumor suppressor 2 homolog

      UniProtKB/TrEMBL
      A0A8M6Z909, E7EYJ6
      Related
      ENSDARP00000098349.2, ENSDART00000112010.4
      Conserved Domains (3) summary
      pfam06818
      Location:390577
      Fez1; Fez1
      pfam11365
      Location:464527
      DUF3166; Protein of unknown function (DUF3166)
      pfam13863
      Location:288372
      DUF4200; Domain of unknown function (DUF4200)