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    itih2 inter-alpha-trypsin inhibitor heavy chain 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406280, updated on 9-Dec-2024

    Summary

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    Official Symbol
    itih2provided by ZNC
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1942
    See related
    Ensembl:ENSDARG00000045516 AllianceGenome:ZFIN:ZDB-GENE-040426-1942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56119; id:ibd5015; wu:fb34d10; wu:fb96f01; DKEY-235I4.1
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in ball; extension; liver; and yolk syncytial layer. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See itih2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25187912..25215968, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25198714..25226770, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto Neighboring gene ATP synthase F1 subunit gamma Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC137491552 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 5 Neighboring gene transmembrane protein 110, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Mehjabin R, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30716520
    2. Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Jima DD, et al. Mol Immunol, 2009 Apr. PMID 19200601, Free PMC Article
    3. What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. Cheung CT, et al. BMC Genomics, 2019 Jul 15. PMID 31307377, Free PMC Article
    4. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
    5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H2
    Names
    inter-alpha (globulin) inhibitor H2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327825.1 → NP_001314754.1  inter-alpha-trypsin inhibitor heavy chain H2 precursor

      Status: VALIDATED

      Source sequence(s)
      BX537116, BX640594
      UniProtKB/TrEMBL
      A0A8M1P9D4, Q5RH29
      Related
      ENSDARP00000066932.4, ENSDART00000066933.6
      Conserved Domains (4) summary
      TIGR03788
      Location:72 → 645
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam06668
      Location:736 → 921
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl00057
      Location:302 → 482
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl02699
      Location:61 → 180
      VIT; Vault protein inter-alpha-trypsin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      25187912..25215968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213007.1: Suppressed sequence

      Description
      NM_213007.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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