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    chia.4 chitinase, acidic.4 [ Danio rerio (zebrafish) ]

    Gene ID: 337333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chia.4provided by ZNC
    Official Full Name
    chitinase, acidic.4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9279
    See related
    Ensembl:ENSDARG00000008541 AllianceGenome:ZFIN:ZDB-GENE-030131-9279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CHIA; chioIIa; zgc:63792; wu:fa55g10
    Summary
    Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chia.4 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (17926279..17933143)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (17999936..18006800)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene calcium-independent phospholipase A2-gamma-like Neighboring gene neurofascin homolog (chicken) b Neighboring gene uncharacterized LOC137489113 Neighboring gene chitinase, acidic.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal expression patterns of chitinase genes in developing zebrafish embryos. Koch BE, et al. Gene Expr Patterns, 2014 Mar. PMID 24418193
    2. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article
    3. Rearing Zebrafish on Black Soldier Fly (Hermetia illucens): Biometric, Histological, Spectroscopic, Biochemical, and Molecular Implications. Vargas A, et al. Zebrafish, 2018 Aug. PMID 29589997
    4. Partial Dietary Inclusion of Hermetia illucens (Black Soldier Fly) Full-Fat Prepupae in Zebrafish Feed: Biometric, Histological, Biochemical, and Molecular Implications. Zarantoniello M, et al. Zebrafish, 2018 Oct. PMID 29912648
    5. Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Xu Y, et al. Front Endocrinol (Lausanne), 2022. PMID 35547009, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63792

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chitinase, acidic.4
    Names
    chia4
    eosinophil chemotactic cytokine
    NP_956740.1
    XP_068072794.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200446.1 → NP_956740.1  chitinase, acidic.4 precursor

      See identical proteins and their annotated locations for NP_956740.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054942
      UniProtKB/TrEMBL
      A0A8M9PSY6, Q7SYA8
      Related
      ENSDARP00000005298.5, ENSDART00000012540.6
      Conserved Domains (3) summary
      cd02872
      Location:25 → 381
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:425 → 473
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:22 → 363
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      17926279..17933143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216693.1 → XP_068072794.1  chitinase, acidic.4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PSY6
    Nucleotide Protein Strain
    Heading Accession and Version

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